Sericin/Poly(ethylcyanoacrylate) Nanospheres by Interfacial Polymerization for Enhanced Bioefficacy of Fenofibrate: In Vitro and In Vivo Studies

Biomacromolecules
Ortensia Ilaria ParisiAnna R Cappello

Abstract

Fenofibrate is a lipophilic drug used in hypercholesterolemia and hypertriglyceridemia as a lipid-regulating agent; however, it is characterized by poor water solubility and low dissolution rate, which result in a low oral bioavailability. In the present study, sericin/poly(ethylcyanoacrylate) nanospheres are synthesized by interfacial polymerization in aqueous media and investigated as a novel sericin-based delivery system for improved and enhanced oral bioefficacy of fenofibrate. The incorporation of sericin into the prepared cyanoacrylate nanoparticles and their spherical shape are confirmed by Lowry assay and scanning electron microscopy, respectively. Hydrophilic and mucoadhesive properties of the synthesized nanospheres are also evaluated. Finally, both in vitro release and in vivo studies are performed and the oral absorbable amount of fenofibrate is calculated to be higher than 70% when incorporated into the polymeric material, reducing the levels of total cholesterol (TC), triacylglycerols (TG), very low-density lipoproteins (VLDL), and low-density lipoproteins (LDL) compared to fenofibrate alone.

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Citations

May 11, 2016·Pharmaceutical Research·Zhiqiang TianWei Wu
May 20, 2016·Korean Journal for Food Science of Animal Resources·Kibbeum SongJungkee Kwon
Dec 22, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Nidhi GuptaSurendra Nimesh
Dec 15, 2016·BioMed Research International·Regina Inês KunzMaria Raquel Marçal Natali
Jan 13, 2018·Soft Matter·Barbara CrivelliMaria Luisa Torre
Jun 23, 2020·Annales pharmaceutiques françaises·M ShitoleS Nangare
Jun 3, 2021·Pharmaceutics·Sara PerteghellaMaria Luisa Torre
Dec 10, 2018·ACS Biomaterials Science & Engineering·Annish JainSonia Kapoor

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