PMID: 3091098Aug 1, 1986

Serine and folate metabolism in fibroblasts from episodic psychotic patients with psychedelic symptoms

Biological Psychiatry
D Fekkes, J Bruinvels

Abstract

A disturbance of serine-glycine metabolism in a group of patients who became psychotic after oral intake of serine may be due to any serine-related enzyme abnormality. In order to elucidate this problem, we studied several enzymes in fibroblasts obtained from these patients. First, the enzyme serine hydroxymethyltransferase was investigated. The apparent Km values for serine, L-tetrahydrofolate (H4folate), and pyridoxal 5'-phosphate, as well as the maximal velocities of the forward and backward reactions measured in fibroblasts obtained from patients, were not different from those in the cells from controls. We also measured the activities of another three enzymes of the folic acid cycle, viz., 5,10-methylene-H4folate dehydrogenase, 10-formyl-H4folate synthetase, and 5,10-methenyl-H4folate cyclohydrolase, as well as the enzyme cystathionine beta-synthase. Again, no differences were found among these enzymes in fibroblasts from patients and controls. It can be concluded that the psychotic symptoms occurring after the administration of serine are not the result of any malfunctioning of the enzymes investigated.

References

May 1, 1977·Journal of Neurochemistry·E MellerA J Friedhoff
Jan 14, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·H RommelspacherG Kossmehl
Oct 15, 1976·Biochemical Pharmacology·N S Buckholtz, W O Boggan
Oct 15, 1973·Biochemical and Biophysical Research Communications·D S Rosenblatt, R W Erbe
Jan 1, 1972·Archives of Biochemistry and Biophysics·D S BroderickJ H Mangum
Sep 1, 1970·Canadian Journal of Biochemistry·D Chippel, K G Scrimgeour
Apr 24, 1968·Biochimica Et Biophysica Acta·Y NakanoH Wada
Mar 1, 1980·Lancet·L PepplinkhuizenP Moleman
Jun 1, 1984·Psychiatry Research·R WaziriJ Mott

Citations

Jun 1, 1992·Biological Psychiatry·G F CarlB K Young
Dec 15, 1992·Biological Psychiatry·T SargentT F Budinger
Nov 1, 1996·Journal of Psychiatric Research·S P Mahadik, S Mukherjee
Feb 9, 2016·Neuroscience·S KálmánK Mirnics

Related Concepts

Aminohydrolases
Cystathionine beta-Synthase
Fibroblasts
Folate
Formate-Tetrahydrofolate Ligase
Methylenetetrahydrofolate Dehydrogenase (NADP+)
Psychoses, Drug
Serine
Glycine Hydroxymethyltransferase
Methenyltetrahydrofolate cyclohydrolase

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