PMID: 3091098Aug 1, 1986

Serine and folate metabolism in fibroblasts from episodic psychotic patients with psychedelic symptoms

Biological Psychiatry
D Fekkes, J Bruinvels


A disturbance of serine-glycine metabolism in a group of patients who became psychotic after oral intake of serine may be due to any serine-related enzyme abnormality. In order to elucidate this problem, we studied several enzymes in fibroblasts obtained from these patients. First, the enzyme serine hydroxymethyltransferase was investigated. The apparent Km values for serine, L-tetrahydrofolate (H4folate), and pyridoxal 5'-phosphate, as well as the maximal velocities of the forward and backward reactions measured in fibroblasts obtained from patients, were not different from those in the cells from controls. We also measured the activities of another three enzymes of the folic acid cycle, viz., 5,10-methylene-H4folate dehydrogenase, 10-formyl-H4folate synthetase, and 5,10-methenyl-H4folate cyclohydrolase, as well as the enzyme cystathionine beta-synthase. Again, no differences were found among these enzymes in fibroblasts from patients and controls. It can be concluded that the psychotic symptoms occurring after the administration of serine are not the result of any malfunctioning of the enzymes investigated.


May 1, 1977·Journal of Neurochemistry·E MellerA J Friedhoff
Jan 14, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·H RommelspacherG Kossmehl
Oct 15, 1976·Biochemical Pharmacology·N S Buckholtz, W O Boggan
Oct 15, 1973·Biochemical and Biophysical Research Communications·D S Rosenblatt, R W Erbe
Jan 1, 1972·Archives of Biochemistry and Biophysics·D S BroderickJ H Mangum
Sep 1, 1970·Canadian Journal of Biochemistry·D Chippel, K G Scrimgeour
Apr 24, 1968·Biochimica Et Biophysica Acta·Y NakanoH Wada
Mar 1, 1980·Lancet·L PepplinkhuizenP Moleman
Jun 1, 1984·Psychiatry Research·R WaziriJ Mott


Jun 1, 1992·Biological Psychiatry·G F CarlB K Young
Dec 15, 1992·Biological Psychiatry·T SargentT F Budinger
Nov 1, 1996·Journal of Psychiatric Research·S P Mahadik, S Mukherjee
Feb 9, 2016·Neuroscience·S KálmánK Mirnics

Related Concepts

Cystathionine beta-Synthase
Formate-Tetrahydrofolate Ligase
Methylenetetrahydrofolate Dehydrogenase (NADP+)
Psychoses, Drug
Glycine Hydroxymethyltransferase
Methenyltetrahydrofolate cyclohydrolase

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.