Abstract
HtrA1, as serine protease lower expressed in various human solid tumors, can down-regulate cell growth and proliferation. In this study, we focus on whether overexpressed HtrA1 can inhibit the growth of gastric cancer in vitro. This study found the HtrA1 is lower expressed in gastric cancer tissue than in normal gastric tissue. When HtrA1 is highly expressing with recombinant plasmid in gastric cancer cell lines SGC-7901 and AGS, it weakened cell proliferation, invasion, and migration in vitro. These data suggested that HtrA1 as an inhibitor in gastric cancer cells resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth and may be an effective molecular targets on gastric cancer treatment.
References
Dec 2, 1996·FEBS Letters·J Zumbrunn, B Trueb
Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H L McLeodJ Cassidy
Sep 21, 2002·Oncogene·Alfonso BaldiMarco G Paggi
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil H SegalAlan N Houghton
Jan 13, 2004·Oncogene·Jeremy ChienViji Shridhar
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yan Ping YuJian-Hua Luo
Nov 16, 2005·Cancer Cell·Sooryanarayana VaramballyArul M Chinnaiyan
Jun 13, 2006·The Journal of Clinical Investigation·Jeremy ChienViji Shridhar
Nov 13, 2008·Journal of Cancer Research and Clinical Oncology·Sebastian ZimmerLukas C Heukamp
Apr 15, 2010·Cancer Research·Xiaoping HeViji Shridhar
Oct 21, 2010·Molecular Pharmacology·Zhi-Jun SunYi-Fang Zhao
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Xiaoping HeViji Shridhar
Sep 6, 2012·Molecular and Cellular Biology·Goo-Young KimHyangshuk Rhim
Sep 29, 2012·Current Pharmaceutical Design·Joanna Skorko-GlonekBarbara Lipinska
Oct 20, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jin XiaQingxia Fan
Feb 5, 2014·Journal of Neuro-oncology·Velia D'AngeloFiorina Casale
Apr 17, 2014·The Journal of Biological Chemistry·Donata FigajJoanna Skorko-Glonek
Jun 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuzhu HouYong Zhao
Jul 9, 2014·The Journal of Biological Chemistry·Yao-Yu ChenHungwen Chen
Citations
Feb 8, 2018·BMC Cancer·Emma AltobelliValerio Filippo Profeta
Nov 30, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Hao ChengYiming Pan
Jun 7, 2017·Oncology Reports·Emma AltobelliDaniela Marzioni
Dec 30, 2020·Medicine·Kai LiQingjun Wei
May 16, 2019·Biochemical and Biophysical Research Communications·Hongxue WuShilun Tong
Jul 3, 2021·Current Oncology·Tzu-Ju ChenHong-Yue Lai
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liangliang WuWeiwei Tang