Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics

British Journal of Pharmacology
David J WilkinsonA D Rowan

Abstract

Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer and arthritis failed clinically, primarily due to poor selectivity for target MMPs. In recent years, roles for serine proteinases in the proteolytic cascades leading to cartilage destruction have become increasingly apparent, renewing interest in the potential for new therapeutic strategies that utilize pharmacological inhibitors against this class of proteinases. Herein, we describe key serine proteinases with likely importance in arthritic disease and highlight recent advances in this field. LINKED ARTICLES: This article is part of a themed section on Translating the Matrix. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.1/issuetoc.

References

May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B V TreadwellH J Mankin
Jul 30, 1990·FEBS Letters·K YamaguchiS Sakiyama
Jul 1, 1995·Annals of the Rheumatic Diseases·L C Tetlow, D E Woolley
Jan 19, 1996·The Journal of Biological Chemistry·V KnäuperG Murphy
Feb 12, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M J Janusz, S L Durham
Jul 3, 1998·The Journal of Clinical Investigation·N BussoA So
Sep 1, 2000·The Journal of Biological Chemistry·H R LijnenP J Declerck
Jun 19, 2001·Biochimica Et Biophysica Acta·H R LijnenD Collen
Jan 4, 2003·The Journal of Clinical Investigation·William R FerrellJunichi Kawagoe
Mar 20, 2003·Bioorganic & Medicinal Chemistry Letters·Mimi L QuanRuth R Wexler
Aug 2, 2005·Arthritis and Rheumatism·Ying Hu, Christine T N Pham
Dec 27, 2005·The Journal of Biological Chemistry·Sandra GrauMichael Ehrmann
May 22, 2007·Biochemical Society Transactions·D QiuV Ellis
Aug 19, 2007·Seminars in Cell & Developmental Biology·Barbara Fingleton
Oct 31, 2007·Arthritis and Rheumatism·H S PalmerW R Ferrell
Dec 14, 2007·Expert Opinion on Therapeutic Targets·Andrew D RowanJennifer M Milner

❮ Previous
Next ❯

Citations

Mar 5, 2019·F1000Research·David A YoungDavid J Wilkinson
Dec 14, 2018·British Journal of Pharmacology·James R WhitefordGiulia De Rossi
Aug 11, 2020·Calcified Tissue International·Kazuhiro YamamotoGeorge Bou-Gharios
Aug 10, 2020·Journal of Proteomics·Elisabetta ChiaradiaBerta Cillero-Pastor
Apr 13, 2021·Biochemical Society Transactions·David J Wilkinson
May 13, 2021·Equine Veterinary Journal·Rhea HaralambusFlorien Jenner
Jan 15, 2022·Cellular and Molecular Life Sciences : CMLS·Yixuan Amy PeiMing Pei
Dec 4, 2020··Ammar Rasoul Mohammed RudhaZahraa Mohammed AL-Nafakh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Medical Bulletin
T E Cawston
European Journal of Oral Sciences
Yasuo Yamakoshi
© 2022 Meta ULC. All rights reserved