Serine/threonine kinases as molecular targets of antidepressants: implications for pharmacological treatment and pathophysiology of affective disorders

Pharmacology & Therapeutics
Maurizio PopoliGiorgio Racagni

Abstract

It is currently a widely accepted opinion that adaptive, plastic changes in the molecular and cellular components of neuronal signaling systems correlate with the effects on mood and cognition observed after long-term treatment with antidepressant drugs. Protein phosphorylation represents a key step for most signaling systems, and it is involved in the regulation of virtually all cellular functions. Two serine/threonine kinases, Ca2+ /calmodulin-dependent protein kinase II and cyclic AMP-dependent protein kinase, have been shown to be activated in the brain following antidepressant treatment. The changes in kinase activity are mirrored by changes in the phosphorylation of selected protein substrates in subcellular compartments (presynaptic terminals and microtubules), which, in turn, may contribute to the modulation of synaptic transmission observed with antidepressants. The molecular consequences of protein kinase activation may account for some of the alterations in neural function induced by antidepressants, and may suggest novel possible strategies of pharmacological intervention.

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Citations

May 3, 2003·Life Sciences·Robert J Donati, Mark M Rasenick
Jan 16, 2003·Neuropharmacology·Rebeca Martinez-TurrillasJoaquín Del Río
Aug 16, 2002·Bipolar Disorders·Maurizio PopoliGiorgio Racagni
Jun 15, 2007·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Ghanshyam N Pandey, Yogesh Dwivedi
Oct 22, 2014·BMC Neuroscience·Laura MusazziDaniela Tardito
Apr 9, 2005·The European Journal of Neuroscience·Laura MusazziMaurizio Popoli
Apr 4, 2013·Journal of Psychiatric Research·Heidi Kaastrup MüllerBetina Elfving
Aug 22, 2003·Molecular Psychiatry·A MorettiR F Villa
Feb 14, 2008·Neurochemical Research·M L TrincavelliC Martini
Jan 16, 2002·The Journal of Biological Chemistry·Ren-Hwa YehDavid S Lawrence
May 1, 2021·International Journal of Molecular Sciences·Kinga SałaciakKarolina Pytka

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