Serious Infections in Rheumatoid Arthritis Offspring Exposed to Tumor Necrosis Factor Inhibitors: A Cohort Study

Arthritis & Rheumatology
Evelyne VinetSasha Bernatsky

Abstract

To evaluate the risk of serious infections in rheumatoid arthritis (RA) offspring exposed to tumor necrosis factor inhibitors (TNFi) in the gestational period compared to unexposed RA offspring, as well as to children from the general population. We used US claim data (2011-2015) to identify 2,989 offspring born to women who have RA and a randomly selected group of 14,596 control children, matched ≥4:1 for maternal age, year of delivery, and state of residence. We defined TNFi exposure based on ≥1 filled prescription during pregnancy. We ascertained serious infections based on ≥1 hospitalization, with infection as a primary diagnosis, at ≤12 months of life. We performed multivariable analyses, adjusting for maternal demographics, comorbidities, pregnancy complications, and drugs. Among RA offspring, 380 (12.7%) were exposed to TNFi during pregnancy. The percentage of serious infections in RA offspring with no TNFi exposure (2.0%; 95% confidence interval [95% CI] 1.5, 2.6) was similar to that in non-RA offspring (1.9%; 95% CI 1.9, 2.2), while the percentage of serious infections in RA offspring with TNFi exposure was 3.2% (95% CI 1.5, 5.6). In multivariable analyses, we were unable to establish an increased risk of serious infec...Continue Reading

References

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Citations

Mar 7, 2019·Current Rheumatology Reports·Nicole Hunt, Mehret Birru Talabi
Oct 19, 2019·PloS One·Christina D ChambersUNKNOWN OTIS Collaborative Research Group
Dec 13, 2019·Zeitschrift für Rheumatologie·R Fischer-Betz, S Späthling-Mestekemper
Mar 25, 2020·Current Opinion in Rheumatology·Mehret Birru Talabi, Megan E B Clowse
Nov 5, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anja GeldhofDanielle Coppola
Jul 27, 2020·Alimentary Pharmacology & Therapeutics·Gabriella BrömsFredrik Granath
Jul 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carla CarnovaleIrene Cetin
May 17, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Jérémie SellamChristophe Richez
Dec 31, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ting-Yun YeLi-Fei Zhu

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