Serious toxicity associated with continuous nevirapine-based HAART in pregnancy

BJOG : an International Journal of Obstetrics and Gynaecology
J E van SchalkwykD M Money

Abstract

This study was designed to determine the safety of nevirapine (NVP)-based highly active antiretroviral therapy (HAART) in a cohort of HIV-positive pregnant women. This was a prospective cohort study of HIV-positive pregnant women. All HIV-positive women treated with HAART during pregnancy from January 1997 to February 2004 at the British Columbia (BC) Women's Hospital in Vancouver, BC, Canada. Demographic and clinical data were collected to compare antiretroviral drug toxicities in women treated antenatally with NVP-based or non-NVP-based HAART. Multivariate analyses were then used to investigate determinants of toxicity. From 1997 to 2004, 103 HIV-positive pregnant women received HAART. Equivalent numbers of women were initially treated with NVP-based (54%) and non-NVP-based (46%) HAART. The groups did not differ by clinical or demographic parameters and duration of HAART exposure was similar between groups. Toxicities necessitating treatment discontinuation were observed in 6 of 56 NVP-exposed women (2 cases each of grade 2, 3, and 4 toxicity) compared with 1 of 47 in the non-NVP-exposed women. First time use of NVP approached significance as a predictor for toxicity, with a toxicity rate of 12.5% (6/48) observed among those ...Continue Reading

References

Jun 24, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jane HittiUNKNOWN PACTG 1022 Study Team
Jan 4, 2006·American Journal of Obstetrics and Gynecology·Esau Custódio JoãoHaroldo J Matos
Jan 30, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lilia JamisseCarey Farquhar
Feb 20, 2007·HIV Medicine·U NatarajanJ Anderson

❮ Previous
Next ❯

Citations

Apr 11, 2009·Current HIV/AIDS Reports·Alice Marie Stek
Jun 18, 2009·AIDS Patient Care and STDs·Silvia BaroncelliUNKNOWN Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy
Oct 24, 2012·Medicinal Research Reviews·Andrew V StachulskiMartin S Lennard
Mar 26, 2014·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Marilia Santini-OliveiraBeatriz Grinsztejn
Apr 17, 2012·International Journal of Hepatology·Manuela G NeumanCharles Parry
Oct 25, 2011·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Philip J PetersTimothy K Thomas
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Amy S SturtTin Tin Sint
Sep 19, 2019·Journal of the International AIDS Society·Lee FairlieMatthew Chersich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.