Sero-epidemiological analysis of the risk of virus infections for childhood leukaemia

International Journal of Cancer. Journal International Du Cancer
B SchlehoferJ R Schlehofer

Abstract

Virus infections have been thought to be involved in the development of childhood leukaemia. In order to address this issue we determined, in a case-control study, the prevalence of antibodies to viruses infecting blood or bone-marrow cells [Epstein-Barr virsus (EBV), human herpes virus type 6 (HHV-6), parvovirus B19] as well as to the human virus known for its tumour-suppressive properties, the adeno-associated virus type 2 (AAV-2), in the sera of 121 children with leukaemia in Germany, and in 197 control individuals, hospitalized for other reasons, and matched for age and gender to the cases. In addition, we developed a questionnaire to be answered by the children's parents, in order to gain information on previous infections of the children as well as to calculate for factors which may influence serological findings. Comparative determination of the prevalence of antibodies against AAV-2, B-19 or HHV-6 revealed no significant differences in cases and controls. However, antibodies to EBV were more frequently found in children with leukaemia younger than 6 years of age (age at the time of diagnosis of leukaemia) than in controls. Apparently, infection with AAV-2 has no protective effect in childhood leukaemia, in contrast to r...Continue Reading

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Citations

Apr 18, 2008·Scandinavian Journal of Infectious Diseases·Matteus J H SalonenMarjaleena Koskiniemi
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Nov 26, 2005·International Journal of Epidemiology·Charles PooleGabor Mezei
Dec 14, 2018·Frontiers in Oncology·Eva EliassenStanley David Hudnall

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