Sero-prevalence of virus neutralizing antibodies for rabies in different groups of dogs following vaccination

BMC Veterinary Research
R M S PimburageK A D N Perera

Abstract

Mass vaccination of dogs is considered fundamental for national rabies control programmes in Sri Lanka, as dog is the main reservoir and transmitter of the disease. Dogs were followed to determine the sero-prevalence of antibodies to the rabies virus. Altogether 510 previously vaccinated and unvaccinated dogs with owners (domestic dogs) and dogs without owners (stray dogs) of the local guard dog breed in different age groups recruited from Kalutara District, Sri Lanka. The dogs were vaccinated with a monovalent inactivated vaccine intramuscularly and serum antibody titres on days 0, 30, 180 and 360 were determined by the Rapid Fluorescent Focus Inhibition Test (RFFIT). The results indicated, a single dose of anti-rabies vaccination fails to generate a protective level of immunity (0.5 IU/ml) which lasts until 1 year in 40.42% of dogs without owners and 57.14% of previously unvaccinated juvenile (age: 3 months to 1 year) dogs with owners. More than one vaccination would help to maintain antibody titres above the protective level in the majority of dogs. The pattern of antibody titre development in annually vaccinated and irregularly vaccinated (not annual) adult dogs with owners is closely similar irrespective of regularity in v...Continue Reading

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Citations

Aug 17, 2018·Clinical and Experimental Vaccine Research·Dong-Kun YangIn-Soo Cho
Nov 4, 2020·Scientific Reports·Aniruddha Belsare, Abi Tamim Vanak
May 1, 2021·Comparative Immunology, Microbiology and Infectious Diseases·J M NaleS A Ingle

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