Seroepidemiological study of hepatitis B virus markers in Japan

Vaccine
Tomoko KiyoharaTakaji Wakita

Abstract

In Japan, since 1986, selective vaccination has been implemented as a hepatitis B prevention strategy. The target of vaccination is the infant born to a hepatitis B surface antigen (HBsAg)-positive mother. The current Japanese hepatitis B prevention strategy focuses on reducing the number of HBV carriers but overlooks the risk to susceptible populations. We conducted a nationwide HBV seroepidemiological study to explore the next hepatitis B control strategy. We used sera derived from healthy individuals collected nationwide from 2005 through 2011 to investigate the HBsAg seroprevalence among children aged 4-9 years and 10-15 years (3000 samples) and hepatitis B core antibody (HBcAb) seroprevalence among people 10-39 years of age (600 samples). Among sera from 3000 children, 5 (0.17%) specimens were HBsAg-positive. There was no significant difference in HBsAg prevalence between age groups. Among 600 samples, 15 (2.5%) were HBcAb-positive. Out of 15 samples, 4 were from teenagers. Both HBsAg- and HBcAb-positive sera were found mainly in the Southern area of Japan. The prevalence of HBsAg among children was 0.17% in the present study. This is higher than the prevalence reported in previous studies performed in the local area or in...Continue Reading

References

Aug 2, 2000·Journal of Gastroenterology and Hepatology·K Shiraki
Jul 16, 2003·Journal of Gastroenterology and Hepatology·Hiroshi NotoUNKNOWN Special Committee for Preventing Hepatitis B in Shizuoka
Jul 21, 2005·Journal of Medical Virology·Hiroshi YotsuyanagiUNKNOWN Japanese Acute Hepatitis B Group
May 23, 2007·Journal of Medical Virology·Hitoshi TajiriMasashi Mizokami
Sep 29, 2009·Bulletin of the World Health Organization·Manju RaniRichard Nesbit
Sep 3, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaya SugiyamaMasashi Mizokami
Apr 29, 2015·Gut and Liver·UNKNOWN Korean Liver Cancer Study Group (KLCSG), UNKNOWN National Cancer Center, Korea (NCC)

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Citations

Jun 10, 2016·PloS One·Serena Y C LinHsin-Fu Liu
Jan 23, 2019·The Journal of Infectious Diseases·Kevin S H LiuMan-Fung Yuen
Sep 9, 2017·Tropical Diseases, Travel Medicine and Vaccines·Kittiyod PoovorawanWatcharapong Piyaphanee
Jan 18, 2019·International Journal of Environmental Research and Public Health·Tingting LiHuan Zeng

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