PMID: 8605591Apr 15, 1996Paper

Seroepidemiology of cytomegalovirus in patients with advanced HIV disease: influence on disease expression and survival

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
D H SheppM H Kaplan

Abstract

To determine the prevalence and effect of cytomegalovirus (CMV) co-infection on clinical outcome, the seroepidemiology of CMV was examined in 196 demographically diverse patients with advanced HIV disease. Thirty-six (18.4%) were seronegative for CMV; 31 of these 36 (86.1%) were both non-black and non-homosexual. Invasive CMV disease developed in 41 of 160 (25.6%) seropositive patients and 0 of 36 (0%) seronegative patients (p = 0.00015). Among seropositive patients, the frequency of CMV disease varied markedly according to risk group for acquisition of HIV infection. CMV disease occurred in 26 of 73 (35.6%) homosexual men and 11 of 33 (33.3%) heterosexuals, but only 2 of 47 (4.3%) injection drug users. Sexual exposure as the only risk factor for the acquisition of HIV was a highly significant independent risk factor for invasive CMV when other covariables were considered in a proportional hazards model (risk ratio 5.4, p = 0.0019). The cumulative proportion of all seropositive patients developing CMV disease after 3 years was 31%. CMV serologic status had no effect on occurrence of AIDS-related illnesses other than CMV disease and no effect on survival. Risk for the development of CMV disease varies substantially among differe...Continue Reading

References

Feb 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W L Drew
Jul 1, 1990·American Journal of Hematology·P R BechererG C White
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M G DavisE S Huang
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Citations

Nov 21, 1998·Diagnostic Microbiology and Infectious Disease·S M LipsonD H Shepp
Feb 4, 1998·Critical Care Clinics·C F Decker, H Masur
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L Rasmussen
Jun 1, 1997·Alimentary Pharmacology & Therapeutics·C M Wilcox, K E Mönkemüller
Feb 24, 2001·AIDS·M RobainUNKNOWN SEROCO/HEMOCO study groups
Mar 6, 2008·Neuroimaging Clinics of North America·Susarla K ShankarJerry M E Kovoor
Feb 1, 1997·AIDS Patient Care and STDs·C M Wilcox
Apr 10, 2003·Journal of Medical Virology·Barbara SuligoiUNKNOWN Italian Seroconversion Study

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