Seroepidemiology of hepatitis E virus infection among preschool children in Taiwan

Journal of Medical Virology
Ding-Bang LinChien-Jen Chen

Abstract

In order to study the seroprevalence of hepatitis E virus (HEV) infection among preschool children in Taiwan, a community-based survey was carried out in 54 kindergartens in 10 urban areas, 10 rural areas, and 2 aboriginal areas randomly selected through stratified sampling. Serum specimens of 2,538 preschool children were screened for HEV antibodies (anti-HEV) by a commercially available enzyme immunoassay. The odd ratios (OR) with 95% confidence intervals (CI) were estimated through multiple logistic regression analysis. A total of 86 children were anti-HEV seropositive, giving a prevalence of 3.4%. The prevalence of anti-HEV was 3.9% (19 of 484) among aboriginal children, a significantly increased seroprevalence compared with that among children who lived in urban areas (OR = 1.68; 95% CI = 1.56-2.95; P < 0.05). Females had a higher anti-HEV seroprevalence than the males (OR = 1.55; 95% CI = 1.14-2.54; P < 0.05). Rates of anti-HEV antibody increased with age in aboriginal areas (chi(2) for trend = 5.59, P = 0.02), but decreased with age in non-aboriginal areas. The poor water supply system, poor sewage disposal, exposure to wild animals, and other environmental conditions in the aboriginal areas might have played a role in t...Continue Reading

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Citations

May 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valsan Philip Verghese, Joan L Robinson
May 6, 2015·Journal of Medical Virology·Qing-Feng MengWei Cong
Oct 28, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Pin-Nan ChengTing-Tsung Chang
Sep 26, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I MaralM A Bumin
Mar 25, 2008·Journal of Medical Virology·Licel de los Angeles Rodríguez LayDavid Anderson
Nov 22, 2005·Journal of Medical Virology·Jye-Bin LinWen-Kang Chen
Mar 7, 2008·Clinical and Vaccine Immunology : CVI·Maria ButiAntoni Plasencia
Apr 16, 2005·International Journal of Epidemiology·K H Jacobsen, J S Koopman
Nov 26, 2011·Expert Review of Anti-infective Therapy·Kenrad E NelsonAlain B Labrique

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