Seroepidemiology of novel influenza A (H1N1) infection among HIV-infected patients in the era of highly active antiretroviral therapy

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Chien-Ching HungShan-Chwen Chang

Abstract

The seroprevalence and seroincidence of novel influenza A infection among HIV-infected patients, who were believed to have more severe outcomes than healthy individuals, are rarely investigated in the era of highly active antiretroviral therapy (HAART). Our aim was to determine the seroprevalence and seroincidence of novel influenza A infection among HIV-infected patients in Taiwan. Between September and November 2009, before the implementation of a nationwide vaccination for novel influenza A in Taiwan, 931 HIV-infected patients and 566 persons seeking voluntary counseling and testing (VCT) for HIV infection at our university hospital were enrolled in this study. Antibody responses to novel influenza A were determined using a hemagglutination-inhibition (HI) assay. HIV-infected patients had a significantly lower seroprevalence of novel influenza A infection than VCT clients (14.7% vs. 33.9%, p < 0.001). The seroincidence of novel influenza A infection among HIV-infected patients was 9.4% (95% confidence interval [CI]: 7.6-11.4). On the multivariate analysis, heterosexual (odds ratio [OR]: 1.89; 95% CI: 1.105-3.227) and baseline HI titer (OR: 1.02; 95% CI: 1.001-1.038) were significantly associated with seroconversion to novel ...Continue Reading

References

Feb 5, 2008·The Journal of Infectious Diseases·Susan MoirAnthony S Fauci
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Oct 10, 2009·The New England Journal of Medicine·Seema JainUNKNOWN 2009 Pandemic Influenza A (H1N1) Virus Hospitalizations Investigation Team
Apr 15, 2010·JAMA : the Journal of the American Medical Association·Mark I C ChenYee Sin Leo
Aug 31, 2010·AIDS·Carlos M PerezMichel Serri

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Citations

Jan 5, 2021·African Journal of Laboratory Medicine·AbdulAzeez A Anjorin, Barakat A Adepoju

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