Serologic, but not Genetic, Markers are Associated with Impaired Anthropometrics at Diagnosis of Pediatric Crohn's Disease

Journal of Pediatric Gastroenterology and Nutrition
Sara K Naramoreand PRO-KIIDS Research Group

Abstract

Children with Crohn's disease may present with malnutrition and linear growth impairment which can be secondary to insufficient caloric intake, chronic inflammation, malabsorption, and suppression of growth-promoting hormones. We evaluated clinical, serologic, and genetic data to determine risk factors for impaired anthropometrics in Crohn's disease at diagnosis. Our study evaluated 772 children newly diagnosed with Crohn's disease, inflammatory phenotype, enrolled in the RISK Stratification Project to determine the factors associated with anthropometric impairment. Data were collected on demographics, growth parameters, disease location, serologic and immunologic markers, and disease severity. We performed a genome-wide association study of genetic polymorphisms associated with inflammatory bowel disease. Regression analysis determined associations between anthropometrics and clinical, serologic, and genetic variables. There were 59 (7%) children with height z-score <-2, 126 (14%) with a weight z-score <-2, and 156 (17%) with a BMI z-score <-2. Linear growth impairment was associated with hypoalbuminemia (p = 0.0052), elevated granulocyte-macrophage colony stimulating factor auto-antibodies (GM-CSF Ab) (p = 0.0110), and elevat...Continue Reading

References

Jan 31, 2009·Journal of Pediatric Gastroenterology and Nutrition·Marian PfefferkornJeffrey Hyams
Aug 29, 2009·Nature Reviews. Gastroenterology & Hepatology·Thomas D Walters, Anne M Griffiths
Apr 20, 2011·Journal of Pediatric Gastroenterology and Nutrition·Cade M NylundLee A Denson
Nov 15, 2011·Digestive Diseases and Sciences·Anna K Trauernicht, Steven J Steiner
Aug 5, 2014·European Journal of Gastroenterology & Hepatology·Denise HerzogUNKNOWN Swiss IBD Cohort Study Group
Jun 23, 2015·PloS One·David J CutlerSubra Kugathasan
Dec 19, 2017·Gene·Martina GirardelliAnna Monica Bianco

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