Serologic cross-reactions among Ehrlichia equi, Ehrlichia phagocytophila, and human granulocytic Ehrlichia.

Journal of Clinical Microbiology
J S DumlerJ E Madigan

Abstract

Homology in the 16S rDNAs shows that the agent of human granulocytic ehrlichiosis (HGE) is closely related to the veterinary pathogens Erlichia equi and Erlichia phagocytophila. After HGE, patients develop antibodies reactive with E. equi and E. phagocytophila; thus, we hypothesized that these species are closely related and share significant antigenicity. Antisera from humans, horses, dogs, and cattle were tested by indirect fluorescent-antibody assay (IFA) for antibodies reactive with E. equi and other ehrlichiae and tested by immunoblot to identify the specific reactions with E. equi. All convalescent-phase sera from human patients with HGE and from animals infected or immunized with E. equi or E. phagocytophila had antibodies reactive with E. equi by IFA; no reactions with Ehrlichia chaffeensis occurred with these sera, and only one horse naturally infected with E. equi had a serologic reaction against Ehrlichia sennetsu. Human and animal sera obtained after infection or immunization with other Ehrlichia, Rickettsia, and Bartonella species did not react with E. equi by IFA. E. equi immunoblots revealed as many as 19 bands with equine anti-E. equi serum. All HGE agent, E. equi, and E. phagocytophila antisera tested reacted w...Continue Reading

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Citations

Mar 24, 1998·Annual Review of Medicine·J S Dumler, J S Bakken
Jul 17, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N PusterlaH Lutz
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S Bakken, J S Dumler
Mar 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S BakkenJ S Dumler
Feb 21, 2002·Infection and Immunity·Karen CaspersenJ Stephen Dumler
Jun 21, 2002·Veterinary Clinical Pathology·Michelle L. PlierJ. Stephen Dumler
Dec 13, 2005·Clinical and Diagnostic Laboratory Immunology·Snorre StuenTruls Moum
Jul 22, 2005·Microbiology and Immunology·Hyo-Soon ParkSeung-Hyun Lee
Jul 8, 2011·Clinical Microbiology Reviews·Yasuko Rikihisa
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