PMID: 9444333Jan 1, 1997Paper

Serologic evidence that streptococcal superantigens are not involved in the pathogenesis of Kawasaki disease

Microbiology and Immunology
A MoritaT Yutsudo

Abstract

Kawasaki disease (KD) is an acute multisystem vasculitis of unknown etiology and is associated with marked activation of T cells and monocyte macrophages, leading to the assumption that superantigens are involved in its pathogenesis. To determine if an association exists between streptococcal superantigens and KD, we examined serum antibody responses to superantigens in sera from 50 paired acute and convalescent KD patients using purified recombinant streptococcal superantigens, such as SPEA, SPEC, SSA and MF. We found a very low frequency of detection of anti-superantigen antibodies by ELISA and no marked IgG seroconversion to each superantigen, indicating the absence of a serological relationship between toxin-producing streptococcal infection and the onset of KD.

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Citations

Apr 23, 2013·The Journal of Infection·Nicola PrincipiSusanna Esposito
Nov 2, 2001·Paediatric Drugs·R V WilliamsL Y Tani
Nov 12, 2013·Trends in Molecular Medicine·Robert J CommonsNigel Curtis
Feb 6, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Luan-Yin ChangLi-Min Huang
Jun 10, 2008·Burns : Journal of the International Society for Burn Injuries·Takaaki MuroTsutomu Saji
Mar 22, 2005·Archives of Medical Research·Chung-Tei ChouChang-Youh Tsai
Apr 12, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Akihiro NakamuraKenji Hamaoka
Jun 7, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David Burgner, Anthony Harnden
Sep 10, 2016·Italian Journal of Pediatrics·Yunjia TangHaitao Lv
Mar 5, 2009·Rheumatology·Cristina C BeliznaYehuda Shoenfeld
Jan 8, 2017·Journal of Cellular and Molecular Medicine·Domenico Del PrincipeElisabetta Straface
Jul 9, 2011·Korean journal of pediatrics·Mi Na LeeYoung Mi Hong
May 2, 2007·Current Opinion in Infectious Diseases·Kousaku Matsubara, Takashi Fukaya
Oct 13, 2006·Current Opinion in Infectious Diseases·A D SawitzkeB C Cole
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Feb 28, 2003·Clinical and Experimental Immunology·P A BroganM J Dillon
Mar 27, 2019·Journal of the Chinese Medical Association : JCMA·Shih-Ming HuangYung-Feng Huang
Jul 19, 2019·Frontiers in Pediatrics·Akihiro NakamuraKenji Hamaoka
Jul 3, 2019·Frontiers in Immunology·Stephanie MenikouMichael Levin
Dec 3, 2004·Pediatrics·Luan-Yin ChangUNKNOWN Kawasaki Disease Research Group

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