Serologic Intestinal-Fatty Acid Binding Protein in Necrotizing Enterocolitis Diagnosis: A Meta-Analysis

BioMed Research International
Shupeng ChengQi Lu

Abstract

Previous studies showed that intestinal-fatty acid binding protein (I-FABP) may be a valid and promising serologic biomarker for early diagnosis of necrotizing enterocolitis (NEC). To investigate the early diagnostic value of serologic I-FABP in NEC for the premature neonates. All major databases were searched from January 1, 1990, to May 1, 2015. We used Meta-Disc 1.4 and Revman5.0 software to calculate the diagnostic accuracy. Seven studies with 444 subjects were identified. The pooled sensitivity of I-FABP was 0.67 for NEC I, 0.74 for NEC II, and 0.83 for NEC III, and the pooled specificity was 0.84, respectively, which showed a moderate diagnostic accuracy. The area under curve (AUC) for each stage was 0.75 (Q (⁎) = 0.69), 0.82 (Q (⁎) = 0.76), and 0.91 (Q (⁎) = 0.84). The diagnostic threshold analysis showed no significant difference in threshold effect. The metaregression showed that the cut-off value has the largest effect on heterogeneity. The funnel plots indicated the existence of publication bias. I-FABP is a valid serologic biomarker for early diagnosis in NEC for the premature neonates with a moderate accuracy.

References

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Citations

Aug 2, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bhawan Deep GargAnju Bansal
Jun 11, 2019·Gastroenterology Research and Practice·Kewei WangKarl G Sylvester
Apr 6, 2017·Journal of Pediatric Gastroenterology and Nutrition·Gianluca TerrinMario De Curtis
May 6, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Grace YoonRobert S Chapkin

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Methods Mentioned

BETA
ELISA

Software Mentioned

QUADAS
Disc
Meta
Revman5

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