Serologic responses to hepatitis C virus in solid organ transplant recipients

Transplantation
J K PreiksaitisL W Chui

Abstract

Hepatitis C (HCV) infection is known to have been transmitted by both blood transfusion and donor organs. We sought to determine the historical incidence of donor- and transfusion-acquired HCV infection in kidney transplant (RTx) and heart transplant (HTx) recipients at our center and to study the kinetics of seroconversion to HCV. A bank of sera collected from organ donors (388 RTx and 88 HTx) who received allografts between January 1984 and April 1992 was screened for anti-HCV using a third generation enzyme immunoassay. Recipient sera collected before transplant (preTx), at 1 year after transplant, and at last follow-up were tested. Fresh follow-up sera on all surviving anti-HCV-positive (+) RTx and HTx, all anti-HCV-negative (-) HTx, and a subset of 85 anti-HCV- RTx were assayed for HCV RNA using an reverse transcriptase-polymerase chain reaction assay. Twenty-four of 388 RTx (6.2%) and 2 of 88 HTx (2.3%) were anti-HCV+ preTx. Eight of 218 (3.7%) organ donors were anti-HCV+. Six of the seven (85.7%) anti-HCV+ donors with adequate recipient follow-up transmitted HCV infection to one or more recipients. Nineteen of 313 RTx (6.1%) and 8 of 72 HTx (11.1%) with follow-up > or =1 year seroconverted to anti-HCV. One of 85 (1.2%) a...Continue Reading

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Citations

Jun 29, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Edward R GarrityEli Gabbay
Jan 6, 2000·Journal of Hepatology·J M Pawlotsky
Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·P R PfauM R Lucey
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Dec 8, 2007·Reviews in Medical Virology·Seema Baid-AgrawalNina Tolkoff-Rubin
May 24, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia BurraMarco Senzolo
Jan 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sean P PinneyDonna Mancini
Aug 10, 2015·The International Journal on Drug Policy·Marianne Martinello, Gail V Matthews
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Nov 8, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S N Natov

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