Serologic studies in patients with keratoconjunctivitis sicca

Archives of Ophthalmology
S L ForstotE M Tan

Abstract

Thirty-two patients with keratoconjunctivitis sicca (KCS) were screened for the presence of antinuclear antibodies, rheumatoid factor, and autoantibodies associated with Sjögren's syndrome (designated SS-A and SS-B). None of these patients had or were found to have clinical evidence of connective-tissue disease. The conditions of 19 (59%) patients were antinuclear-antibody-positive and 18 (56%) were rheumatoid-factor-positive. We found SS-A and/or SS-B autoantibodies in ten (31%) patients. There seems to be a high incidence of serologic abnormalities in patients with KCS, even when those patients with connective-tissue disease are excluded. Serologic testing seems to be a useful adjunct in the early diagnosis of primary Sjögren's syndrome. The presence of SS-A and SS-B autoantibodies correlated well with the clinical diagnosis of Sjögren's syndrome and seemed to identify the conditions of patients who may have a higher incidence of systemic complications with KCS.

Citations

Sep 27, 2002·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Pauline ChoSin Wan Cheung
Dec 23, 2003·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Pauline ChoS W Cheung
Sep 5, 2002·Arthritis and Rheumatism·Daniel H SolomonUNKNOWN American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines
Sep 15, 2005·Cornea·Steven J DonnellyJenna M Burka
Dec 1, 1986·Ophthalmology·S C PflugfelderR L Font
Jan 6, 2004·The Journal of Craniofacial Surgery·Jorge Orlando Güerrissi, Javier Belmonte
Dec 1, 1988·Acta Ophthalmologica·A K Khurana, S S Moudgil

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