PMID: 6969593Nov 1, 1980Paper

Serologic subsets in systemic lupus erythematosus: an examination of autoantibodies in relationship to clinical features of disease and HLA antigens

Arthritis and Rheumatism
D A Bell, P J Maddison

Abstract

A search for anti-Ro or anti-nRNP antibodies by precipitin analysis among a population of 64 patients with systemic lupus erythematosus (SLE) or mixed connective tissue disease was undertaken. The 25% of SLE patients with anti-Ro did not have any distinct clinical features, compared to patients without anti-Ro or to anti-nRNP patients with SLE or mixed connective tissue disease. However, these patients did have a significantly greater frequency of rheumatoid factor (80%). Most importantly however, patients with anti-Ro had a significantly increased frequency of HLA-B8 (81%) and HLA-DRw3 (100%) compared to patients with anti-nRNP (B8--29%; DRw3--33%) or SLE patients without such antibodies (B8--41%; DRw3--25%). These data suggest the existence of a specific immune response gene for Ro close to the D region of the major histocompatibility complex.

References

Jan 1, 1976·Tissue Antigens·B G SolheimE Thorsby
Feb 1, 1978·American Journal of Clinical Pathology·P I TerasakiY Iwaki
Aug 1, 1979·Annals of Internal Medicine·M Martinez-LavinE M Tan
Sep 1, 1977·Arthritis and Rheumatism·E M TanE V Barnett
Mar 1, 1978·Arthritis and Rheumatism·L G ClelandB C Saurino
Sep 7, 1978·The New England Journal of Medicine·J L ReinertsenD L Mann
Jul 1, 1976·Tissue Antigens·D IványiL Mrklas
May 1, 1975·The Journal of Clinical Investigation·M A Alspaugh, E M Tan
Apr 21, 1977·The New England Journal of Medicine·T M ChusedP I Terasaki
Oct 1, 1977·Tissue Antigens·M E GershwinT A Gorman
Nov 1, 1974·Annals of Internal Medicine·D Alarcón-SegoviaY González-Jiménez
Dec 1, 1965·Arthritis and Rheumatism·J J CondemiJ H Vaughan
Dec 1, 1962·Annals of the Rheumatic Diseases·J R ANDERSONA J McELHINNEY

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Citations

May 20, 1998·Arthritis and Rheumatism·J S Smolen, G Steiner
May 1, 1990·Arthritis and Rheumatism·E GenthP W Hartl
Apr 1, 1992·Arthritis and Rheumatism·M ReichlinM D Lockshin
Sep 1, 1986·Journal of Clinical Immunology·M Reichlin
Jan 1, 1986·Springer Seminars in Immunopathology·M B Stevens
Jan 1, 1986·Springer Seminars in Immunopathology·J Buyon, I Szer
Dec 1, 1993·Clinical Rheumatology·L T Costallat, A M Coimbra
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Julie H LinVictoria P Werth
Jul 1, 1985·Clinics in Dermatology
Mar 26, 2003·Human Immunology·Maurizio MarchiniRaffaella Scorza
Oct 14, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·B T WalshL C Clark
Mar 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·O Anusaksathien, A E Dolby
May 1, 1986·Annals of the Rheumatic Diseases·C VitaliS Bombardieri
Jan 1, 1988·Annals of the Rheumatic Diseases·P J VenablesR N Maini
Jul 1, 1988·Postgraduate Medical Journal·G R Hughes
May 23, 1998·Annual Review of Immunology·T J Vyse, B L Kotzin
Mar 1, 1987·The Journal of Clinical Investigation·K K GaitherJ B Harley
May 1, 1991·The Journal of Clinical Investigation·F C ArnettJ D Reveille
Sep 1, 1992·The Journal of Clinical Investigation·E C De Mendonca NetoP H Schur
Jan 1, 1981·Springer Seminars in Immunopathology·E L Alexander, T T Provost
Dec 21, 2002·Scandinavian Journal of Rheumatology·Lucia PantojaJuan Ortiz-Saracho
Dec 14, 2007·Autoimmunity·Bahram NamjouJohn B Harley
Jan 1, 1989·Autoimmunity·D J Gawkrodger
Jan 1, 1982·Journal of the American Academy of Dermatology·H L Wechsler, A Stavrides
Jan 1, 1985·Journal of the American Academy of Dermatology·J F FowlerP K Cotter

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