Serological and genomic characterization of equine rotavirus VP4 proteins identifies three different P serotypes

Virology
P Isa, D R Snodgrass

Abstract

A series of viral reassortants was prepared between equine rotaviruses H1 (G5), H2 (G3), and L338 (G13) and human rotavirus ST3 (G4). All contained the VP4 cognate gene segment 4 from the equine parental virus and the VP7 cognate gene segment 9 from ST3. Using these viruses and antisera prepared to them, it was shown that each of the three equine viruses possessed a serologically distinct VP4 or P serotype with a > or = 16-fold difference in reciprocal cross-neutralization titers. H1 VP4 was closely related to that of porcine virus OSU, i.e., P7. L338 gene 4 was sequenced, and the sequence and serological data indicated that it constituted a novel P serotype L338. P serotype H2 was predominant among our cell culture-adapted equine rotavirus strains, but showed some serological cross-reactivity.

Citations

Aug 22, 2008·Journal of Clinical Microbiology·P J CollinsH O'Shea
Jul 5, 2003·Journal of Clinical Microbiology·Felipe Mota-HernándezFernando I Puerto
Mar 23, 2012·Veterinary Microbiology·Souvik GhoshNobumichi Kobayashi
Sep 3, 2013·Vaccine·Hajnalka PappKrisztián Bányai
Oct 31, 2003·Virology·Ferdinando LiprandiMax Ciarlet
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Oct 26, 1999·Revista Do Instituto De Medicina Tropical De São Paulo·J D MascarenhasA C Linhares
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Oct 16, 1999·Veterinary Immunology and Immunopathology·L A van PinxterenD R Snodgrass
Jun 10, 1998·Journal of Clinical Microbiology·L Padilla-NoriegaC F Arias

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