Serological and Progression Differences of Joint Destruction in the Wrist and the Feet in Rheumatoid Arthritis - A Cross-Sectional Cohort Study

PloS One
Yosuke HamamotoShuichi Matsuda

Abstract

To investigate clinical and radiological differences between joint destruction in the wrist and the feet in patients with RA. A cross-sectional clinical study was conducted in an RA cohort at a single institution. Clinical data included age, sex and duration of disease. Laboratory data included sero-positivity for anti-cyclic citrullinated peptide (CCP) antibody and RF. Radiological measurements included Larsen grades and the modified Sharp/van der Heijde method (SHS) for the hands/wrists and the feet. Statistical analyses were performed using the Kruskal-Wallis H-test, a dummy variable linear regression model and multivariate logistic regression analysis with 95% confidence interval and odds ratios. A total of 405 patients were enrolled, and 314 patients were analysed in this study. The duration of disease in the foot-dominant group was significantly less than that in the wrist-dominant group. When patients were subdivided by duration of disease, the Larsen grade of the feet was significantly higher than that of the wrist in the first quadrant subgroup, but this was reversed with increasing duration of disease. Anti-CCP status was a significant predictive factor for joint destruction in the wrist but not in the feet, while RF ...Continue Reading

References

Jun 17, 2009·BMC Musculoskeletal Disorders·Adriana Rojas-VillarragaJuan-Manuel Anaya
Mar 18, 2010·Arthritis Care & Research·Wanruchada KatchamartClaire Bombardier
Jul 17, 2012·Annals of the Rheumatic Diseases·Elisa GremeseGianfranco Ferraccioli
Apr 11, 2013·Annals of the Rheumatic Diseases·J A B van NiesA H M van der Helm-van Mil
Jun 5, 2013·The Journal of Rheumatology·Annemarie KrabbenAnnette H M van der Helm-van Mil
Oct 10, 2013·Arthritis Care & Research·Takumi MatsumotoKatsumi Ito
Jan 24, 2014·PloS One·Chikashi TeraoTsuneyo Mimori
Mar 22, 2014·Scandinavian Journal of Rheumatology·M FuruT Mimori

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Citations

Apr 7, 2016·Journal of Clinical Immunology·Timothy J VeceJordan S Orange
Nov 28, 2019·Mediators of Inflammation·Qinghua FangKutty Selva Nandakumar
Sep 13, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Marie-Louise Frémond, Nadia Nathan

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