PMID: 373782Feb 1, 1979

Serological aspects of rat tumour xenograft growth in athymic nude mice

British Journal of Cancer
M V Pimm, R W Baldwin


The serum of athymic nude mice bearing rat tumour xenografts has been examined for tumour-specific antigen. With a sarcoma and a hepatoma, tumour-specific antigen expression continued in xenograft growths, and sera of tumour-bearing mice contained free antigen, assayed by its ability to neutralise reactivity of tumour-immune rat sera against tumour target cells in an indirect membrane-immunofluorescence test. In contrast, no anti-rat antibody was detectable in sera of mice bearing the xenografts, or rejecting cells injected in admixture with BCG.


Related Concepts

Tumor Antibodies
Tumor Antigens
Surface Antigens
Immunofluorescence Assay
Hepatoma, Novikoff
Mice, Inbred Strains
Mice, Nude
Neoplasm Transplantation
August Rats
Sarcoma, Jensen

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