PMID: 6109151Dec 20, 1980Paper

Serological classification of chronic cholestatic liver disease by the use of two different types of antimitochondrial antibodies

Lancet
P BergH Lindner

Abstract

Clinical and morphological features in fifteen patients with chronic cholestatic liver disease (mixed form) who had two different types of complement-fixing antimitochondrial antibodies were compared with those found in twenty-five patients with classic primary biliary cirrhosis (PBC). PBC-specific antimitochondrial antibody (M2) directed against an antigen of the inner mitochondrial membrane was always present in both groups. However, mixed-form cases had a second antimitochondrial antibody (M4) which fixed complement with a trypsin insensitive antigen probably located on the outer membrane. Histological lesions typical of chronic active hepatitis, often associated with granulomata formation and bileduct proliferation, and simultaneous increases in IgM and IgG were predominant features, indicating that these mixed-form cases may represent a separate clinical entity.

References

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Citations

Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M E GershwinI R Mackay
Oct 1, 1986·Klinische Wochenschrift·P A Berg, R Klein
Jul 1, 1986·Digestive Diseases and Sciences·R P KennyE R Dickson
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F LozanoJ Vives
Jan 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Manns, K H Meyer zum Büschenfelde
Aug 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K H Meyer zum BüschenfeldeT Poralla
Jul 1, 1987·Digestive Diseases and Sciences·T OkunoT Takino
Aug 26, 1998·The American Journal of Gastroenterology·M OhanaK Uchida
Jan 4, 1998·Journal of Gastroenterology and Hepatology·M P Manns
May 1, 1990·Journal of Gastroenterology and Hepatology·I R Mackay
Jan 1, 1986·Annals of the New York Academy of Sciences·E Carafoli
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N D Smith, J L Boyer
Apr 1, 1988·Journal of Bioenergetics and Biomembranes·I GhadiminejadH Baum
Mar 17, 2000·Journal of Gastroenterology and Hepatology·I R Mackay
Aug 17, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Christoph P BergPeter A Berg
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P WeberP A Berg
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E PennerJ Gordon
Sep 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G R FlanneryH Baum
Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MannsK H Meyer Zum Büschenfelde
May 28, 2019·Frontiers in Immunology·Yann BeckerEric Boilard
May 24, 1995·Biochimica Et Biophysica Acta·H Baum
Oct 26, 1984·Journal of Immunological Methods·J G KennaR Williams
Jan 1, 1982·Journal of Immunological Methods·F L Meek
Jul 1, 1987·Baillière's Clinical Gastroenterology·P A Berg, R Klein

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