PMID: 16622538Apr 20, 2006Paper

Serological detection of anti HPV 16/18 and its association with pap smear in adolescents and young women

Revista da Associação Médica Brasileira
Cristina Helena RamaCorintio Mariani Neto

Abstract

Verify the relation between HPV 16/18 antibodies and the association with cervical cytology findings in adolescents and young women. A cross sectional study with 541 healthy and sexually active women from 15 to 25 years of age was carried on from September to November 2000. At gynecological examination, a cervical sample on liquid-base for cytology-testing and a blood sample for ELISA identification of HPV 16 and 18 antibodies were collected and sent to a reference laboratory in Belgium. Statistical analysis estimated the prevalence and prevalence ratio with a 95% confidence interval. Of these young women, 150 (27.7%) were seropositive: 79 (14.6%) to HPV 16 antibody; 35 (6.4%) to HPV 18 antibody and 36 (6.6%) to both HPV 16/18 antibodies. Cytological abnormalities were detected in 107 cases (20.5%): 63 presented with atypical squamous cells of undetermined significance (ASCUS), 41 were suggestive of low grade squamous intra-epithelial lesion (LGSIL) and 3 of high grade squamous intra-epithelial lesion (HGSIL). Prevalence of abnormal cytology with a positive serology was only 1.75 times that of prevalence of abnormal cytology with a negative serology. Detection of abnormal cytology was not correlated with positive serology. Resu...Continue Reading

Citations

Mar 28, 2013·Cadernos de saúde pública·Carolina Maciel Reis GonzagaAna Paula Magalhães Resende
Jan 31, 2013·Journal of Clinical Laboratory Analysis·Amanda C FidelisMaria M D Maia
Jan 18, 2008·Revista de saúde pública·Cristina Helena RamaJosé Mendes Aldrighi
Aug 31, 2010·Revista Da Sociedade Brasileira De Medicina Tropical·Camila Aparecida CiriloErika Zambrano
Mar 7, 2009·The Journal of General Virology·Stina SyrjänenMichael Pawlita
Jun 3, 2009·Cadernos de saúde pública·Denise Leite Maia MonteiroFábio Bastos Russomano
Sep 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Salvatore VaccarellaUNKNOWN IARC HPV Prevalence Surveys Study Group

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