Serological determinants of COVID-19

Biology Direct
Annalisa NoceNicola Di Daniele

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spreaded rapidly worldwide, as far as it has become a global pandemic. Therefore, the introduction of serological tests for determination of IgM and IgG antibodies has become the main diagnostic tool, useful for tracking the spread of the virus and for consequently allowing its containment. In our study we compared point of care test (POCT) lateral flow immunoassay (FIA) vs automated chemiluminescent immunoassay (CLIA), in order to assess their specificity and sensibility for COVID-19 antibodies detection. We find that different specificities and sensitivities for IgM and IgG tests. Notably IgM POCT FIA method vs CLIA method (gold standard) has a low sensitivity (0.526), while IgG POCT FIA method vs CLIA method (gold standard) test has a much higher sensitivity (0.937); further, with respect of IgG, FIA and CLIA could arguably provide equivalent information. FIA method could be helpful in assessing in short time, the possible contagiousness of subjects that for work reasons cannot guarantee "social distancing".

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Citations

Feb 2, 2021·Frontiers in Microbiology·Yu FuYirong Li
Mar 23, 2021·Saudi Journal of Biological Sciences·Nisreen Naser Al AwajiElrashed B Yasin
Jun 3, 2021·International Journal of Molecular Sciences·Almerinda Di VenereGiampiero Mei
Aug 7, 2021·Cell Death & Disease·David Della-MorteNicola Di Daniele

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Methods Mentioned

BETA
ELISA
sandwich immunoassay

Software Mentioned

caret
POCT
MAGLUMI
R

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