Serological diagnosis and follow-up of asymptomatic and acute Q fever infections

International Journal of Medical Microbiology : IJMM
Christiane Wagner-WieningPeter Kimmig

Abstract

During an outbreak of Q fever at a farmer's market in Soest (North Rhine-Westphalia, Germany) in 2003, we examined 263 serum samples of presumably infected persons for Q fever antibodies. One hundred and seventy-one of these patients were tested positive for acute Q fever infection. Furthermore, 29 persons of certain risk groups like pregnant women (n=11) or patients with valvular heart disease (n=18) were examined. Among these, in four pregnant women and two heart patients an acute but asymptomatic infection could be diagnosed. With 30 patients we performed a serological follow-up for 8-60 weeks. In our study, phase 2 (PH2)-IgM antibodies as a marker for acute infection were present in all 30 patients 3-4 weeks after onset of clinical signs and disappeared 3-4 months later. Six weeks to three months after clinical manifestation, all patients developed PH1-IgG antibodies in low levels with no clinical signs of chronic Q fever. Three patients, including one pregnant woman showed high-level titres and were treated for chronic Q fever. Eleven patients with low PH1-IgG antibodies and all three patients with high titres developed IgA antibodies from 10 weeks after clinical manifestation; therefore PH1-IgA cannot be used as the only ...Continue Reading

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Citations

Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hervé Tissot-DupontDidier Raoult
Apr 12, 2013·PloS One·Gabriëlla MorroyPeter M Schneeberger
Mar 13, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J C J P HagenaarsO H J Koning
Apr 5, 2013·European Journal of Clinical Investigation·Cornelia C H WieldersWim van der Hoek
Aug 16, 2015·Veterinary Microbiology·M Ganter
Jun 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wim van der HoekPeter M Schneeberger
Nov 20, 2016·Clinical Microbiology Reviews·Carole EldinDidier Raoult
Feb 13, 2019·Internal Medicine Journal·Phongsakone InthavongCraig A Aboltins

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