Serological evaluation of possible exposure to Ljungan virus and related parechovirus in autoimmune (type 1) diabetes in children

Journal of Medical Virology
A-L NilssonA Lernmark

Abstract

Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n = 69) with healthy controls (n = 294), all from the Jämtland County in Sweden, using an exploratory suspension multiplex immunoassay for IgM and IgG against 26 peptides of LV, human parechoviruses (HPeV), Aichi virus and poliovirus in relation to a radiobinding assay (RBA) for antibodies against LV and InfluenzaA/H1N1pdm09. Islet autoantibodies and HLA-DQ genotypes were also determined. 1) All five LV-peptide antibodies correlated to each other (P < 0.001) in the suspension multiplex IgM- and IgG-antibody assay; 2) The LV-VP1_31-60-IgG correlated with insulin autoantibodies alone (P = 0.007) and in combination with HLA-DQ8 overall (P = 0.022) as well as with HLA-DQ 8/8 and 8/X subjects (P = 0.013); 3) RBA detected LV antibodies correlated with young age at diagnosis (P < 0.001) and with insulin autoantibodies (P < 0.001) especially in young HLA-DQ8 subjects (P = 0.004); 4) LV-peptide-VP1_31-60-IgG correlated to RBA LV antibodies (P = 0.009); 5) HPeV3-peptide-IgM and -IgG showed inter-peptide corr...Continue Reading

References

Dec 10, 1990·FEBS Letters·A S Kolaskar, P C Tongaonkar
Dec 20, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·I KockumA Lernmark
Oct 30, 2001·Annals of Medicine·P Joki-Korpela, T Hyypiä
Apr 30, 2002·Diabetes·Jinko GrahamUNKNOWN Swedish Childhood Diabetes Study Group
May 15, 2003·International Journal of Experimental Diabesity Research·Bo NiklassonAke Lernmark
Sep 30, 2005·Proceedings. Biological Sciences·Birger HörnfeldtUlf Eklund
Apr 26, 2006·Immunome Research·Jens Erik Pontoppidan LarsenMorten Nielsen
Apr 17, 2009·The New England Journal of Medicine·Patrick ConcannonGerald T Nepom
Jul 10, 2009·The New England Journal of Medicine·Vincenzo SepeGian Franco Bottazzo
Aug 30, 2011·Protein Expression and Purification·Ali SheikholvaezinJonas Blomberg
Jul 4, 2012·Viral Immunology·Sabina Rešić LindehammerÅke Lernmark
May 15, 2013·Archives of Virology·Anne-Marie SalisburyJames P Stewart
Jul 16, 2013·Journal of Medical Virology·P KolehmainenS Tauriainen
Jul 16, 2013·Journal of Medical Virology·Anne J JääskeläinenOlli Vapalahti
Nov 12, 2013·Journal of Autoimmunity·Mihaela StefanYaron Tomer

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Citations

Aug 6, 2016·Autoimmunity Reviews·Teresa Rodriguez-CalvoMatthias G von Herrath
May 22, 2016·The Journal of General Virology·Hiromichi MitakeMakoto Sugiyama
Oct 11, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cristina FevolaAntti Vaheri
Feb 14, 2017·Journal of Wildlife Diseases·Cristina FevolaHeidi C Hauffe
Jul 18, 2018·Pediatric Diabetes·Åshild Olsen Faresjö, Johnny Ludvigsson
Jul 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Guoyan ZhaoHerbert W Virgin
May 23, 2021·The Journal of General Virology·Annika LundstigAnna-Lena Nilsson

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