Serological evidence of exposure to Rift Valley, Dengue and Chikungunya Viruses among agropastoral communities in Manyara and Morogoro regions in Tanzania: A community survey

PLoS Neglected Tropical Diseases
Rule M BudodoJaffu Chilongola

Abstract

Tanzania has recently experienced outbreaks of dengue in two coastal regions of Dar es Salaam and Tanga. Chikungunya and Rift Valley Fever outbreaks have also been recorded in the past decade. Little is known on the burden of the arboviral disease causing viruses (Dengue, Rift Valley and Chikungunya) endemically in the inter-epidemic periods. We aimed at determining the prevalence of the dengue, rift valley and chikungunya among humans in two geo ecologically distinct sites. The community-based cross-sectional study was conducted in Magugu in Manyara region and Wami-Dakawa in Morogoro region in Tanzania. Venous blood was collected from participants of all age groups, serum prepared from samples and subjected to ELISA tests for RVFV IgG/IgM, DENV IgG/IgM, and CHIKV IgM/IgG. Samples that were positive for IgM ELISA tests were subjected to a quantitative RT PCR for each virus. A structured questionnaire was used to collect socio-demographic information. Data analysis was performed by using SPSSv22. A total of 191 individuals from both sites participated in the study. Only one individual was CHIKV seropositive in Magugu, but none was seropositive or positive for either RVFV or DENV. Of the 122 individuals from Wami-Dakawa site, 16....Continue Reading

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Citations

Jul 10, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sima RugarabamuLeonard E G Mboera
Aug 25, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Gaspary O MwanyikaLeonard E G Mboera

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Methods Mentioned

BETA
ELISA
enzyme linked immunosorbent assay
PCR

Software Mentioned

ArcGIS
SPSS

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