Serological evidence of SV40 infections in HIV-infected and HIV-negative adults

Journal of Medical Virology
S JafarJanet S Butel

Abstract

SV40 is a simian polyomavirus that was a contaminant of some viral vaccines administered to people between 1955 and 1962. SV40 DNA has recently been found associated with several types of human tumors, suggesting that the virus is present in humans. We examined sera from patients infected with human immunodeficiency virus type 1 (HIV-1) as well as from HIV-1-negative controls to determine the prevalence of SV40 neutralizing antibodies using a specific plaque reduction assay. We found that 16.1% of HIV-infected patients (n = 236) were seropositive for SV40, as compared to 12.0% of HIV-negative control volunteers (n = 108) and 11.1% of HIV-negative patients (n = 72). These differences were not statistically significant. As individuals born between 1941 and 1962 had the highest chance of having received SV40-contaminated poliovaccines, we analyzed SV40 seropositivity rates based on year of birth. SV40 antibody rates for HIV-infected patients born before 1941, between 1941 and 1962, and after 1962 were 17.1%, 16.3%, and 11.8%, respectively. For the HIV-negative subjects, the rates were 12.5%, 12.0%, and 9.7%, respectively. There was no correlation between SV40 seropositivity and either the stage of disease in HIV-infected patients ...Continue Reading

References

Oct 1, 1976·The Journal of General Virology·R M Dougherty
Oct 15, 1977·International Journal of Cancer. Journal International Du Cancer·E BethG Giraldo
Jan 1, 1976·American Journal of Epidemiology·K Shah, N Nathanson
May 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·P Brown, J A Morris
Jun 1, 1977·International Journal of Biometeorology·I S Longmuir, L Pashko
Apr 9, 1992·The New England Journal of Medicine·D J BergsagelR L Garcea
Nov 1, 1992·Journal of Virology·P O IlyinskiiR C Desrosiers
Jun 1, 1990·The Journal of Infectious Diseases·T KitamuraY Yogo
Jul 1, 1988·The Journal of Infectious Diseases·C A AndrewsR H Rubin
Jul 1, 1986·Journal of Medical Virology·T FlaegstadJ Joergensen
Mar 1, 1972·American Journal of Epidemiology·K V Shah
Dec 1, 1973·The Journal of Infectious Diseases·K V ShahR M Warszawski
Jul 1, 1980·The Journal of Infectious Diseases·D V ColemanA M Field
Feb 1, 1984·Experimental and Molecular Pathology·J S ButelD Medina
Jun 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·L VagoG Costanzi
Jan 1, 1996·Journal of Clinical Microbiology·H T AgostiniG L Stoner
Aug 1, 1997·Nature Medicine·M CarboneH I Pass

❮ Previous
Next ❯

Citations

Mar 19, 2002·Lancet·Regis A VilchezJanet S Butel
Dec 28, 2002·Journal of Virology·Riccardo DolcettiMauro Tognon
Jul 20, 2004·Clinical Microbiology Reviews·Regis A Vilchez, Janet S Butel
Feb 11, 2005·Molecular Medicine·Cristina MorelliMauro Tognon
Jul 11, 2007·Infectious Agents and Cancer·Fernanda MartiniMauro Tognon
Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eun Jeong KwakShimon Kusne
Jun 19, 2004·Leukemia & Lymphoma·Janet S ButelClaudia A Kozinetz
Mar 17, 2012·Experimental Hematology·Elisa MazzoniMauro Tognon
May 8, 2013·Reviews in Medical Virology·Ugo MoensBernhard Ehlers
Jan 26, 2005·The Journal of Infection·Zhannat Z NurgalievaJanet S Butel
Nov 7, 1998·The Journal of Thoracic and Cardiovascular Surgery·H I PassM Carbone
May 20, 2008·Virology·Landon W WestfallRonald C Kennedy
Jun 12, 2003·The American Journal of Medicine·Regis A VilchezJanet S Butel
Jan 2, 2003·Journal of the National Cancer Institute·Howard D StricklerPhilip S Rosenberg
Oct 16, 2003·Journal of the National Cancer Institute·Joseph J CarterDenise A Galloway
Jan 29, 1999·Journal of the National Cancer Institute·J S Butel, J A Lednicky
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Elisa MazzoniMauro G Tognon
May 18, 2004·International Journal of Cancer. Journal International Du Cancer·Mauro TognonGiuseppe Barbanti-Brodano
Jul 22, 2006·Scandinavian Journal of Infectious Diseases·Fernanda MartiniMauro Tognon
May 27, 2003·Journal of Medical Virology·P MinorW Knowles
Jul 15, 2003·Journal of Medical Virology·Wendy A KnowlesElizabeth Miller
Nov 9, 2018·The Journal of General Virology·Aboud Kourieh For The Split Study Group
Feb 8, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Regis A VilchezJanet S Butel
Aug 12, 2003·Oncogene·Regis A Vilchez, Janet S Butel
Feb 23, 2007·International Journal of Cancer. Journal International Du Cancer·Kristina KjaerheimMichael Pawlita
Sep 17, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A Kazory, D Ducloux
Feb 17, 2009·The Journal of General Virology·Parmjeet RandhawaNeil D Christensen
Aug 14, 2019·Frontiers in Oncology·John Charles RotondoFernanda Martini
May 20, 2004·Journal of the National Cancer Institute·Giuseppe Barbanti-BrodanoMauro Tognon
Sep 28, 2002·Transplantation·Regis A VilchezShimon Kusne
Jul 19, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Regis A VilchezJanet S Butel
Mar 13, 2001·Seminars in Cancer Biology·M J ImperialeM G Sanda

❮ Previous
Next ❯

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

© 2022 Meta ULC. All rights reserved