Serological follow-up of SARS-CoV-2 asymptomatic subjects

Scientific Reports
Gregorio Paolo MilaniUNICORN Consortium

Abstract

SARS-CoV-2 symptoms are non-specific and can range from asymptomatic presentation to severe pneumonia. Asymptomatic subjects carrying SARS-CoV-2 often remain undiagnosed and it is still debated whether they develop immunoglobulins (Ig) and how long they persist. The aim of this study was to investigate the development and persistence of antibodies against SARS-CoV-2 in asymptomatic subjects infected by the virus. This follow-up study was performed on the 31 asymptomatic subjects who presented a positive nasal swab or serology against SARS-CoV-2 (Ig against Spike-RBD) in the first part of the UNICORN study (March 2020) aimed at attesting previous or current contacts with the virus in the personnel of the University of Milan. Eight weeks after the first Ig measure, these subjects were invited to donate a second blood sample for testing serum antibodies (IgM, IgG and total antibodies) and to fill-in a structured questionnaire. About 80% of asymptomatic subjects did not present circulating immunoglobulins against SARS-CoV-2 after 8 weeks from a positive nasal swab against the virus. Moreover, in more than 40% of these subjects, no Ig against SARS-CoV-2 were detected at any time. Finally, about two third of subjects with immunoglobu...Continue Reading

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Citations

Apr 4, 2021·Microorganisms·Kirsten Alexandra EberhardtVeronica Di Cristanziano
May 1, 2021·Pathogens·Gregorio P MilaniFranco Muggli
May 1, 2021·Viruses·Giulia Matusali Inmi Covid-Laboratory Team
May 5, 2021·Practical Laboratory Medicine·Elizabeth Fontaine, Cristian Saez
May 2, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Catharina GerhardsVerena Haselmann
Jun 18, 2021·BMC Infectious Diseases·Bianca A TrombettaSara Suliman
Jul 2, 2021·Journal of Virological Methods·Suraj JagtapRahul Roy
Aug 12, 2021·Open Forum Infectious Diseases·Patrick W G MallonUNKNOWN All Ireland Infectious Diseases Cohort Study Group
Sep 1, 2021·BMC Infectious Diseases·UNKNOWN COVID-19 Community Research Partnership Study Group
Aug 10, 2021·The Annals of Thoracic Surgery·HelenMari Merritt-GenoreUNKNOWN Society of Thoracic Surgeons Workforce on Critical Care
Sep 15, 2021·Infectious Diseases·Hiie SoeorgIrja Lutsar

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
ELISA
Enzyme-Linked Immunosorbent Assay

Software Mentioned

R
SAS

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