PMID: 9194037Jan 1, 1997Paper

Serological indicators of Helicobacter pylori infection in adult dyspeptic patients and healthy blood donors

Microbiology and Immunology
T RechcińskiW Rudnicka

Abstract

The levels of IgM, IgG and IgA antibodies reacting with two Helicobacter pylori antigens (glycine acid extract (GE) and a recombinant CagA protein) were determined in the sera from adult dyspeptic patients, positive (H.p.(+)) or negative (H.p.(-)) for H. pylori urease/culture, and from healthy blood donors. All sera were also examined against GE by Western blot (Immunoblot) technique. Similar levels of anti-GE IgG were detected in the sera from all H.p.(+) and almost all H.p.(-) patients and from over 40% of the healthy volunteers. In contrast, higher levels of anti-GE IgA were found in the sera from patients than that from healthy subjects, although such antibodies were not detected in the sera from 30% of the H.p.(+) patients. In general, our results suggest that a combination of ELISA and immunoblot may be more sensitive in the detection of H. pylori infection in dyspeptic patients than the examination of biopsy specimens by culturing or histology.

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Citations

Mar 27, 2001·FEMS Immunology and Medical Microbiology·W RudnickaM Chmiela
Nov 2, 2011·Microbiology and Immunology·Karolina RudnickaMagdalena Chmiela
Oct 14, 2016·PloS One·Susheela D Biranjia-Hurdoyal, Sharmila P Seetulsingh-Goorah
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Feb 13, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Weronika GonciarzMagdalena Chmiela
Oct 15, 2003·Cancer Science·Mitsue UedaChieko Miyake
Sep 28, 2016·World Journal of Gastroenterology : WJG·Eliza MnichMagdalena Chmiela
May 10, 2003·FEMS Immunology and Medical Microbiology·Wieslawa RudnickaMagdalena Chmiela
May 10, 2003·FEMS Immunology and Medical Microbiology·Magdalena ChmielaWieslawa Rudnicka
Jun 14, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Karolina RudnickaMagdalena Chmiela
Mar 11, 2020·International Journal of Molecular Sciences·Weronika GonciarzMagdalena Chmiela

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