Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis

Alimentary Pharmacology & Therapeutics
M J NielsenMette Vesterhus

Abstract

Primary sclerosing cholangitis is a progressive liver disease with a remarkably variable course. Biomarkers of disease activity or prognostic models predicting outcome at an individual level are currently not established. To evaluate the prognostic utility of four biomarkers of basement membrane and interstitial extracellular matrix remodeling in patients with primary sclerosing cholangitis. Serum samples were available from 138 large-duct primary sclerosing cholangitis patients (of which 102 [74%] with IBD) recruited 2008-2012 and 52 ulcerative colitis patients (controls). The median follow-up time was 2.2 (range 0-4.3) years. Specific biomarkers of type III and V collagen formation (PRO-C3 and PRO-C5, respectively) and type III and IV collagen degradation (C3M and C4M, respectively) were assessed. The Enhanced Liver Fibrosis test, including procollagen type III N-terminal peptide, tissue inhibitor of metalloproteinase-1 and hyaluronic acid was assessed for comparison. All markers were elevated in primary sclerosing cholangitis compared to ulcerative colitis patients (P < 0.001). PRO-C3 showed the largest difference between the two groups with a threefold increase in primary sclerosing cholangitis compared to ulcerative coliti...Continue Reading

References

Jul 8, 2003·The Journal of Pathology·Fred T Bosman, Ivan Stamenkovic
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Dec 23, 2008·Scandinavian Journal of Gastroenterology·Inger Camilla SolbergUNKNOWN IBSEN Study Group
Mar 13, 2009·Biochemical and Biophysical Research Communications·Roel G M BreulsTheo H Smit
Jun 9, 2009·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roger ChapmanUNKNOWN American Association for the Study of Liver Diseases
Jul 30, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Sanne S VeidalMorten A Karsdal
Jun 19, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kirsten BoonstraUNKNOWN EpiPSCPBC Study Group
Jan 1, 2014·Alimentary Pharmacology & Therapeutics·T H KarlsenK M Boberg
Oct 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Mette J NielsenKeyur Patel
Feb 20, 2015·Current Opinion in Gastroenterology·Elisabeth M G de VriesCyriel Y Ponsioen
Apr 3, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mette VesterhusTom H Karlsen
Sep 4, 2015·Histopathology·Richard CollingKenneth Fleming
Feb 26, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ki M MakM Png
Sep 16, 2016·Diabetologia·Morten A KarsdalDetlef Schuppan
Oct 22, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Morten A KarsdalDetlef Schuppan
Dec 14, 2016·Alimentary Pharmacology & Therapeutics·A J Montano-LozaA L Mason
Feb 6, 2017·Journal of Hepatology·Mette VesterhusFridtjof Lund-Johansen
Mar 8, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Elisabeth M G de VriesMette Vesterhus

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Citations

Aug 31, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Morten A KarsdalDetlef Schuppan
May 18, 2019·Journal of Digestive Diseases·James B Maurice, Douglas Thorburn
Jan 31, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Morten A KarsdalDetlef Schuppan
Jun 12, 2020·Alimentary Pharmacology & Therapeutics·Signe WieseFlemming Bendtsen
Mar 31, 2020·Journal of Gastroenterology·Mette Vesterhus, Tom Hemming Karlsen
May 19, 2020·Alimentary Pharmacology & Therapeutics·Ida Falk VillesenMette Juul Nielsen
Nov 24, 2020·JHEP Reports : Innovation in Hepatology·Mette VesterhusDouglas Thorburn
Feb 16, 2021·Scandinavian Journal of Gastroenterology·Amandeep Kaur DhillonJohannes R Hov
Jun 25, 2021·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.euUNKNOWN Panel members:
May 30, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Francesca SaffiotiDouglas Thorburn
Dec 1, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Nikolaj TorpAleksander Krag

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