Serological reactivity to MPB83 and CFP10/ESAT-6 antigens in three suid hosts of Mycobacterium bovis infection

Veterinary Microbiology
Michele MillerK P Lyashchenko

Abstract

Domestic pigs and wild suids are susceptible to Mycobacterium bovis (M. bovis) infection and may even serve as reservoir hosts in some situations. Therefore, detection of infected animals is important for understanding their role in the epidemiology of the disease as well as for management and control of bovine tuberculosis. Infected suids develop strong humoral responses, making serological screening a feasible approach to disease surveillance. However, to optimize sensitivity of the antibody assays, it is necessary to identify and incorporate immunodominant antigens recognized by the target species. The objective of this study was to characterize the antigen recognition by three suid species in a commercially available serological test, DPP VetTB Assay. Serum samples from naturally M. bovis-infected domestic pigs, wild boar and common warthogs were tested. MPB83 protein appeared to be the immunodominant antigen recognized by antibodies in all three species. Overall test sensitivity was increased in wild suids when seroreactivity to CFP10/ESAT-6 antigen was included. Infected animals with visible lesions showed more robust antibody responses than those without gross lesions. The high sensitivity and specificity of the DPP VetT...Continue Reading

Citations

Jan 11, 2021·Transboundary and Emerging Diseases·Tanya J KerrMichele A Miller
Feb 26, 2021·Veterinary Research·Jobin ThomasMaría A Risalde
Apr 14, 2020·Tuberculosis·Michelle H LarsenRichard T Robinson
Jan 24, 2020·Comparative Immunology, Microbiology and Infectious Diseases·Konstantin P LyashchenkoW Ray Waters
Jul 28, 2021·Veterinary Immunology and Immunopathology·Konstantin P LyashchenkoW Ray Waters

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