PMID: 8945710Nov 1, 1996Paper

Serological response to Chlamydia pneumoniae in patients with sarcoidosis

The Journal of Infection
M PuolakkainenP Saikku

Abstract

The antigen-specific serological response to Chlamydia pneumoniae was studied in 24 patients with sarcoidosis and compared to that seen in acute C. pneumoniae respiratory infection. By the micro-immunofluorescence test, five sarcoidosis patients had acute antibody, 15 had chronic antibody and four had no antibody against C. pneumoniae. By enzyme immunoassay, 20 sarcoidosis patients had antibody against ReLPS but that cross-reacts with chlamydial LPS. Immunoblot analysis of sera using purified C. pneumoniae elementary bodies showed that recognition of the 40 kDa C. pneumoniae major outer membrane protein was rare (20%). Reactivities with proteins with Mw of 42 K (70%), 60 K (65%), 98 K (55%) and 52 K (50%) were often noted. To study reactivity of chlamydial HSP 60 in sarcoidosis sera, sarkosyl-soluble (contains the 60 kDa HSP) and sarkosyl-insoluble (contains the 60 kDa structural protein) fractions of C. pneumoniae elementary bodies were prepared. The 60 kDa structural protein was recognized with equal frequency by sera from patients with sarcoidosis and acute respiratory infection, while the HSP 60 was more frequently recognized by sera with acute respiratory infection than sarcoidosis. Recombinant fusion proteins expressed fr...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1976·Annals of the New York Academy of Sciences·O RefvemK Loe
Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R HammerschlagJ Schachter
Aug 1, 1991·The Journal of Infectious Diseases·J F CampbellJ S Spika
Aug 1, 1991·Thorax·B A CrosseM M Muers
Jul 10, 1991·JAMA : the Journal of the American Medical Association·D L HahnR Golubjatnikov
Apr 1, 1990·The Journal of Infectious Diseases·J T GraystonS P Wang
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H BradeF E Nano
Jan 1, 1989·Scandinavian Journal of Infectious Diseases·M ErntellK Persson
Mar 1, 1989·The Journal of Experimental Medicine·R P MorrisonH D Caldwell
Oct 1, 1984·Annals of Internal Medicine·A A HarrisS Levin
Sep 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R EkmanP Saikku

❮ Previous
Next ❯

Citations

May 5, 2004·Journal of Hepatology·Ahmad S AbdulkarimKeith D Lindor
Oct 25, 2000·Journal of Microbiological Methods·T TuuminenJ Paavonen
Mar 24, 2004·Nature Reviews. Microbiology·Lee Ann Campbell, Cho-cho Kuo
Feb 18, 2003·Journal of Internal Medicine·R M du BoisP Cullinan
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·L A CampbellC C Kuo Cc
Sep 14, 2002·Infection and Immunity·Jens GieffersHarlan D Caldwell
Aug 16, 2005·American Journal of Respiratory and Critical Care Medicine·Deirdre M KellyNoel G McElvaney
Jan 26, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Y KidoT Nakazawa
Mar 20, 2010·The Clinical Respiratory Journal·Robert HörsterChristoph Lange
Feb 3, 2015·Scandinavian Journal of Immunology·M SuchankovaM Bucova
Jun 9, 1998·Respiratory Medicine·G Zissel, J Müller-Quernheim
Feb 13, 2001·Pulmonary Pharmacology & Therapeutics·L Allegra, F Blasi
Mar 1, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F. BlasiL. Allegra
Jul 2, 2010·Current Opinion in Pulmonary Medicine·Lowie E G W Vanfleteren, Catharina F M Linssen
Oct 31, 2006·World Journal of Gastroenterology : WJG·Antonella MarangoniRoberto Cevenini
Nov 30, 2016·BMC Pulmonary Medicine·Tiago EstevesVicente Garcia-Patos
Apr 20, 2001·Journal of the American Academy of Dermatology·J C EnglishK E Greer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.