Serological response to HPV16 in CIN-III and cervical cancer patients. Case-control studies in Spain and Colombia

International Journal of Cancer. Journal International Du Cancer
Silvia de SanjoséV Vonka

Abstract

This study evaluates the association of antibodies against HPV-16-derived peptides with cervical cancer and estimates the sensitivity and specificity of the serological assays in relation to HPV DNA detection in cervical cells by PCR. Study subjects were derived from 4 case-control studies carried out in Spain and Colombia. Sera from 544 cases of CIN III and invasive cancer and of 543 age-matched controls were tested for antibodies to 5 peptides derived from E2, E7 (3 partially overlapping frames of HPV 16 denoted E7/ 1, E7/2, E7/3) and L2 open reading frames of HPV 16. HPV DNA was detected using a L1-PCR based method. Among cancer controls, antibody response to E2 and E7/1, E7/2, E7/3 was higher in Colombia (22.5%,7.2%,11.7%,12.6% respectively) than in Spain (17.1 %, 4.7%, 5.9%, 5.9%). E7 antibodies were related to stage, particularly in CIN III vs. invasive stages and less markedly within invasive stages. Detection of antibodies to the E7/1 was associated to CIN III (OR = 1.8). The risk of invasive cervical cancer was increased among those with antibodies to E2 (OR = 2.2), to E7/1 (OR = 4.2), to E7/2 (OR = 4.3), and to E7/3 (OR = 2.5). Presence of antibodies to all the 3 E7 peptides increased the risk of CIN III (OR = 5.6) an...Continue Reading

References

Nov 11, 1992·International Journal of Cancer. Journal International Du Cancer·N MuñozN Ascunce
Mar 15, 1990·International Journal of Cancer. Journal International Du Cancer·J DillnerD DiLuca
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·R P ViscidiK V Shah

❮ Previous
Next ❯

Citations

Apr 15, 2014·International Journal of Cancer. Journal International Du Cancer·Jean-Damien CombesGary Clifford
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·V VonkaM Smahel
Jun 23, 2000·Clinical Obstetrics and Gynecology·R H KaufmanV Vonka
Mar 10, 2001·The Journal of Pathology·A Giannoudis, C S Herrington
Feb 23, 2007·International Journal of Cancer. Journal International Du Cancer·C Sloane FurnissKarl T Kelsey
Jun 17, 2003·Journal of the National Cancer Institute. Monographs·Sophia S Wang, Allan Hildesheim
Jun 18, 1999·Reviews in Medical Virology·J DillnerJ Schiller
Dec 16, 1997·International Journal of Cancer. Journal International Du Cancer·G TerryJ Cuzick
Sep 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Salvatore VaccarellaUNKNOWN IARC HPV Prevalence Surveys Study Group
Dec 6, 2001·Experimental and Molecular Pathology·S J GhimA B Jenson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2021 Meta ULC. All rights reserved