PMID: 60289Aug 15, 1976Paper

Serologically detectable specific and cross-reactive antigens on the membrane of a polyoma virus-induced murine tumor

International Journal of Cancer. Journal International Du Cancer
I P WitzG Klein

Abstract

With the aid of an assay measuring complement-dependent cytotoxocity mediated by syngeneic antibodies, we performed a serological analysis of surface antigens of a polyoma-virus-induced murine tumor (SEYF-a). In vivo propagated SEYF-a ascites tumor cells expressed a specific membrane antigen in addition to various other cross-reacting antigens. Among these we could identify at least four separate specificities. Two of these were present on MuLV-induced lymphoma cells, the first on Moloney-virus-induced YAC cells and the second on Gross-virus-induced GHA cells. The third cross-reacting antigen was detected on EL-4 cells. At least one additional specificity was present on two methylcholantthrene-induced murine sarcomas. Normal syngeneic lymphoid cells were insensitive to cytotoxicity mediated by the anti-tumor antisera. Quantitative and perhaps also qualitative differences between that antigenic expression of in vivo propagated on cultured SEYF-a cells were indicated. These studies show that hyperimmune sera produced in syngeneic mice against transplanted tumors may contain a considerable number of antibody specificities, only some of which are specific for the tumor. Furthermore, the results also suggest that polyoma-virus-induc...Continue Reading

References

Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·M RanI P Witz
Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·G BataillonG Klein
Oct 14, 1969·Annals of the New York Academy of Sciences·D W Weiss
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J P GrantD P Bolognesi
Dec 1, 1950·British Journal of Cancer·P A GORER

❮ Previous
Next ❯

Citations

Jan 1, 1982·Springer Seminars in Immunopathology·M Vandeputte
Jan 1, 1992·Immunologic Research·I P Witz, M Ran
May 15, 1979·International Journal of Cancer. Journal International Du Cancer·G KleinI Witz
Mar 15, 1979·International Journal of Cancer. Journal International Du Cancer·P H ClevelandY H Pilch
Aug 1, 1976·European Journal of Immunology·G R BraslawskyI P Witz
Dec 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N KuzumakiG Klein
Aug 15, 1981·International Journal of Cancer. Journal International Du Cancer·C K Grant, M T Michalek

❮ Previous
Next ❯

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.