Seroma prevention using an albumin-glutaraldehyde-based tissue adhesive in the rat mastectomy model

Annals of Plastic Surgery
Nathan G MenonRonald P Silverman

Abstract

Seroma formation is a common postoperative complication in plastic surgery, resulting in notable patient morbidity and expense. In this study the authors investigated the efficacy of a synthetic glutaraldehyde-based tissue adhesive (BioGlue; Cryolife, Inc., Kennesaw, GA) in seroma prevention in the rat mastectomy seroma model. This tissue adhesive is composed of purified bovine serum albumin (45%) and glutaraldehyde (10%). Twenty-two Sprague-Dawley rats received mastectomies along with axillary lymphadenectomy and disruption of subcutaneous lymphatics. The control group (N = 11) received 2.5 ml saline into the wound before closure. In the experimental group (N = 11), 2.5 ml BioGlue was injected into the wound. On postoperative day 7, the resultant seromas were quantified and adjacent tissues were harvested for histological examination. The rats in the control group had a mean seroma volume of 5.19 ml (standard deviation, +/- 3.65 ml; N = 11), whereas the rats treated with BioGlue had a mean seroma volume of 0.25 +/- 0.43 ml (N = 11). Histology revealed an inflammatory response consistent with postoperative changes as well as a mild foreign body reaction. This study demonstrates that BioGlue can be used as a tissue adhesive that...Continue Reading

References

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Citations

Sep 26, 2008·Tissue Engineering. Part B, Reviews·Peter N Zawaneh, David Putnam
Sep 9, 2006·The Breast Journal·Thomas L ChungRonald P Silverman
Jan 11, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Tanya Yuen, Andrew H Kaye
Apr 13, 2005·Otolaryngologic Clinics of North America·Stephen T Flock, Kevin S Marchitto
Apr 17, 2007·Nature Materials·Dong-An WangJennifer H Elisseeff
Feb 10, 2021·Ear, Nose, & Throat Journal·Bugra Subasi, Ender Guclu

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