PMID: 22358366Feb 24, 2012Paper

Seronegative cat-scratch disease diagnosed by PCR detection of Bartonella henselae DNA in lymph node samples

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Konstantinos ChondrogiannisGeorgios Fragulidis

Abstract

Cat scratch disease (CSD), the typical clinical manifestation of Bartonella infections usually follows a typical benign self-limited course. Nevertheless, a variety of unusual clinical manifestations and confusing imaging features can lead to misinterpretations and render the disease a diagnostic dispute. Routine laboratory tests exhibit varying reported sensitivity and are usually unhelpful in diagnosis, as serology fails in terms of specificity and/or sensitivity. Herein we report a case of seronegative Bartonella infection presenting as symptomatic suppurative lymphadenitis with abscess formation, which was surgically drained. Diagnosis was established by PCR analysis from lymph nodes samples obtained during the procedure. PCR detection of specific DNA fragments from lymph node biopsy provides a sensitive detection of disease. The technique should be considered for patients with suspected CSD and negative serology, since serological assays exhibit low sensitivity. In ambiguous cases, surgical exploration may provide tissue for diagnosis; it is well tolerated and affords improved recovery.

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Citations

Apr 17, 2013·Parasites & Vectors·Ricardo G MaggiEdward B Breitschwerdt
Oct 31, 2013·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hiroyuki IijimaHiroshi Takahashi
Dec 17, 2014·International Journal of Family Medicine·Liesbeth BorgermansDirk Devroey
Jun 27, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Sasagu KimuraShouichi Ohga
Apr 30, 2016·Case Reports in Radiology·Taylor RisingPauravi Vasavada
Oct 5, 2013·Annales de dermatologie et de vénéréologie·M NajiG Guillet
Nov 10, 2015·The American Journal of Surgical Pathology·Christine E JabcugaRebecca L King

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