Seronegative reactive spondyloarthritis and the skin

Clinics in Dermatology
Elena GeneraliCarlo Selmi

Abstract

Spondyloarthritidies represent a group of conditions affecting the axial and peripheral muscoloskeletal apparatus and are often associated with psoriasis, infections, and inflammatory bowel diseases. Other diseases included in this category are psoriatic arthritis, ankylosing spondylitis, and enteropathic arthritis. Reactive arthritis is an elusive spondyloarthritis, commonly occurring 1 to 3 weeks after a digestive or a genitourinary tract infection, in which microorganisms do not infect the joint directly. Reactive arthritis is classically characterized by large-joint arthritis, urethritis in men and cervicitis in women, and eye inflammation (usually conjunctivitis or uveitis) but encompasses numerous other symptoms and signs, including manifestations of dermatologic interest such as keratoderma blenorrhagicum and circinate balanitis. The diagnosis of reactive arthritis is clinical, and the infectious agent cannot always be identified due to disease latency after the infection. Most cases are self-limiting, but reactive arthritis may become chronic in 30% of cases. Treatment options include anti-inflammatory drugs, steroids, and sulfasalazine; biologic agents, such as tumor necrosis factor α (TNF-α) blockers, have been recent...Continue Reading

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Citations

Oct 24, 2015·Clinical Reviews in Allergy & Immunology·Elena GeneraliCarlo Selmi
Sep 1, 2015·Clinics in Dermatology·Nikolai TsankovRazvigor Darlenski
Jun 23, 2018·European Journal of Clinical Investigation·Anthony W Segal
Jul 29, 2017·Clinical Reviews in Allergy & Immunology·Carolyn Jean Chua-AguileraNikhil Yawalkar
Nov 27, 2021·International Journal of Dermatology·Daniel R NemirovskyRena D Malik

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