Seroprevalence and mother-to-infant transmission of hepatitis C in asymptomatic Egyptian women

European Journal of Obstetrics, Gynecology, and Reproductive Biology
R M KumarP F Hughes

Abstract

In this study, we sought to determine (1) the prevalence of hepatitis C virus (HCV) RNA, or its antibodies, in a healthy parturient Egyptian population and (2) the risk of mother-to-infant transmission in this population. The serum of 499 pregnant Egyptian women was tested for anti-HCV with ELISA-3 and for HCV RNA by polymerase chain reaction (PCR). Neonatal cord blood and infant blood were similarly tested for anti-HCV and HCV RNA. Recombinant immunoblot assay (RIBA) detected anti-HCV in 65/499 (13%) women; of these, 20/65 (31%) were PCR-positive. The total number of babies born was 499. Of the original group, 97 mothers and infants (HCV-negative) were lost to follow up and were excluded. Sixty-five anti-HCV-positive infants were born vaginally to the 65 anti-HCV-positive mothers, of which twenty (31%) corresponding mothers and babies were also positive for HCV RNA. Of these twenty babies, three died of hepatocellular disease by six months of age; sixteen developed chronic liver disease; the remaining nine remained asymptomatic but were serologically and PCR-positive. The mother-to-infant transmission rate was significantly increased (5%; P < 0.0001). Of the seropositive children, 45/65 (69%; P < 0.0001) seroreverted by eighte...Continue Reading

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Citations

Nov 15, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·P CombeUNKNOWN DYSCER-CI Study Group
Feb 5, 2000·The New England Journal of Medicine·A H BirnbaumL Moy
Apr 28, 2004·Infectious Diseases in Obstetrics and Gynecology·Youyin ChoyPeter G McGovern
May 26, 2012·TheScientificWorldJournal·Mohamed A Daw, Aghnaya A Dau
Aug 23, 2006·Archives of Disease in Childhood·S M DavisonD A Kelly
Jun 18, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·William SievertFrancesco Negro
Nov 1, 2008·International Journal of Cancer. Journal International Du Cancer·Elizabeth M Lehman, Mark L Wilson
Sep 6, 2008·American Journal of Obstetrics and Gynecology·Moya B McMenaminFionnuala M McAuliffe
Jul 20, 2004·Journal of Medical Virology·François RouetUNKNOWN ANRS 1236 DITRAME-B&C Study Group
Nov 16, 2004·Arquivos De Gastroenterologia·Mário Ferreira PeixotoAna Maria Ponzio de Azevedo
Oct 21, 2006·The Cochrane Database of Systematic Reviews·P G McIntyreW McGuire
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Apr 30, 2015·Infectious Diseases·Abdelfattah M AttallahAhmed A Attallah
Apr 24, 2020·American Journal of Perinatology·Alexandra AndesKimberly Fryer

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