PMID: 9431898Feb 12, 1998Paper

Seroprevalence of hepatitis A virus and Helicobacter pylori infections in the general population of a developed European country (the San Marino study): evidence for similar pattern of spread

European Journal of Gastroenterology & Hepatology
S PretolaniG Gasbarrini

Abstract

To evaluate the role of faecal-oral transmission in the spread of Helicobacter pylori. A cross-sectional comparison of the patterns of hepatitis A and H. pylori seropositivity. At interview, blood samples and questionnaire data were collected from a random sample of 1528 healthy subjects aged 20-85 years from the Republic of San Marino. Serum samples from each subject were then tested for anti-H. pylori and anti-hepatitis A antibodies. Overall, 529 of 670 H. pylori-seropositive subjects (78.9%) and 460 of 858 H. pylori-seronegative subjects (53.6%) were hepatitis A seropositive (P<0.01; odds ratio=3.2; confidence interval 95%=2.6-4.1). This association remained after adjustment by a multiple logistic regression analysis for the confounding effect of age and length of schooling, as surrogate for socio-economic status (OR=2.0; CI 95%=1.3-3.3). The age-specific prevalence curves for H. pylori and hepatitis A infections showed a parallel increase by age, although to a lesser extent for H. pylori. These findings provide evidence that in the community studied H. pylori may have spread in a manner similar to that of hepatitis A.

Citations

Jun 23, 2004·Occupational and Environmental Medicine·S JeggliP Hotz
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hoda M MalatyTsutomu Katsuyama
Jul 7, 1999·The Journal of Hospital Infection·C L Williams
Dec 10, 1999·Immunopharmacology and Immunotoxicology·A Di LeoE Jirillo
Jun 25, 2008·Infection·R MonnoUNKNOWN Albanian-Italian collaborating group
Apr 14, 2015·Japanese Journal of Infectious Diseases·Meng-Che WuKuen-Der Yang
Nov 26, 2015·Alimentary Pharmacology & Therapeutics·S E RobertsJ G Williams
Aug 18, 2004·Annals of Saudi Medicine·Mohtaram Nassrolahei, Alireza Khalilian

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