Seroprevalence of Hepatitis B Among HIV-infected Children and Adolescents Receiving Antiretroviral Therapy in the TREAT Asia Pediatric HIV Observational Database

The Pediatric Infectious Disease Journal
Linda AurpibulTREAT Asia Pediatric HIV Observational Database (TApHOD) of IeDEA Asia-Pacific

Abstract

Hepatitis B (HBV)-HIV coinfection is associated with liver inflammation, which can progress to liver fibrosis/cirrhosis and hepatocellular carcinoma. We determined HBV seroprevalence in children and adolescents participating in the TREAT Asia Pediatric HIV Observational Database. A multisite cross-sectional study was conducted in HIV-infected patients currently <25 years old receiving antiretroviral treatment (ART) who had HBV surface antigen (HBsAg), or HBV surface antibody (anti-HBs) or HBV core antibody (anti-HBc) tested during 2012-2013. HBV coinfection was defined as having either a positive HBsAg test or being anti-HBc positive and anti-HBs negative, reflective of past HBV infection. HBV seroprotection was defined as having a positive anti-HBs test. A total of 3380 patients from 6 countries (Vietnam, Thailand, Cambodia, Malaysia, Indonesia and India) were included. The current median (interquartile range) age was 11.2 (7.8-15.1) years. Of the 2755 patients (81.5%) with HBsAg testing, 130 (4.7%) were positive. Of 1558 (46%) with anti-HBc testing, 77 (4.9%) were positive. Thirteen of 1037 patients with all 3 tests were anti-HBc positive and HBsAg and anti-HBs negative. One child was positive for anti-HBc and negative for an...Continue Reading

References

Jul 25, 2007·Journal of Gastroenterology and Hepatology·Jialun ZhouUNKNOWN TREAT Asia HIV Observational Database
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·François RouetUNKNOWN Programme Enfant Yopougon (Agence Nationale de Recherches sur le SIDA et les Hépatites Virales B et C 1244/1278)
May 14, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Georgios K NikolopoulosAngelos Hatzakis
Jan 12, 2010·HIV Medicine·G BrookUNKNOWN BHIVA Viral Hepatitis Working Group
May 18, 2012·The Pediatric Infectious Disease Journal·Linda AurpibulThanyawee Puthanakit
Nov 14, 2015·Japanese Journal of Clinical Oncology·Hai-Rim ShinCherian Varghese

❮ Previous
Next ❯

Citations

Aug 24, 2020·Clinics and Research in Hepatology and Gastroenterology·Rayana Maryse ToyéCoumba Touré-Kane

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.