Seroprevalence of HHV-8 infection in the pediatric population of two university hospitals in Rio de Janeiro, Brazil

International Journal of Dermatology
João Carlos Regazzi AvelleiraElizabeth de Los Santos-Fortuna

Abstract

The authors present a serologic survey of the prevalence of herpesvirus-8 (HHV-8) among 171 children from 0 to 12 years old in Rio de Janeiro, Brazil. Sera were tested for latent nuclear and lytic antigens using indirect immunofluorescence and Western blotting. Serology for HHV-8 was positive in 16 of 171 patients (9.35%). Among 13 HIV-positive patients, four (31%) were also positive for HHV-8. The seropositivity among healthy children was 7.6%, and females were significantly (P<0.002) more associated with HHV-8 seropositivity (16%) than males (1.1%). We detected a higher HHV-8 seroprevalence among the pediatric population in Rio de Janeiro, Brazil, when compared with similar studies performed in other countries. Nonsexual routes of transmission are a possible explanation for this pattern. The unusual finding of a higher seroprevalence among female children could be explained by a specific route of exposition or even an epidemiological bias.

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Citations

Feb 10, 2010·International Journal of Cancer. Journal International Du Cancer·Sheila C DollardJeffrey N Martin
Nov 23, 2017·Journal of Tropical Pediatrics·Marcelo Comerlato ScottaBento Vidal de Moura Negrini

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