Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4-24 years in Turkey

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
M CevikC Aybay

Abstract

The distribution of IgG antibodies to Bordetella pertussis was investigated in serum samples from 550 subjects, aged 4-24 years, to determine the optimal age for booster immunisation. Levels of antibody to B. pertussis antigens were determined using an ELISA that measures a mixture of pertussis toxin, filamentous haemagglutinin and lipopolysaccharide. Geometric mean titres of anti-pertussis antibodies in subjects aged 4-6 years were significantly lower than those in other age groups, which reflects waning immunity following vaccination. High positive titres in older children and adolescents suggested acquired B. pertussis infection, and booster doses at the ages of 7 and 15 years are therefore suggested.

References

May 15, 2001·Epidemiology and Infection·A DomínguezL Salleras
May 15, 2003·Vaccine·Marie Van der WielenClaire-Anne Siegrist
Nov 14, 2003·The Pediatric Infectious Disease Journal·Siranda Torvaldsen, Peter B McIntyre
May 13, 2006·Epidemiology and Infection·M CagneyA Giammanco
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James D Cherry

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Citations

Dec 20, 2012·Expert Review of Vaccines·Romina Libster, Kathryn M Edwards
May 23, 2019·Human Vaccines & Immunotherapeutics·Yuyang XuYan Liu

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