Seroprevalence of neutralizing antibodies against human adenovirus type 55 in the South Korean military, 2018-2019

PloS One
So Yun ParkSoon-Hwan Kwon

Abstract

We conducted a seroprevalence study of a large ongoing outbreak of human adenovirus type 55 (HAdV-55) among the military in South Korea. Serum samples were collected between 2018 and 2019 from military-exposed (military group) and non-exposed (non-military group) populations. The plaque reduction neutralization test (PRNT) was used to assess neutralization activity against HAdV-55. A total of 100 sera was collected from the non-military group, of which 18.8% showed HAdV-55 neutralizing antibody activity. Ninety-six sera were tested from the military group, which had significantly higher prevalence of neutralizing antibodies (56.0%, P <0.001). A significantly higher proportion of the military group had PRNT titers ≥1:1,000 than the non-military group (85.7% vs. 50.0%, P = 0.004). Among the military group, 48.9% of active-duty soldiers had PRNT titers ≥1:5,000, while none of the discharged civilians did (P = 0.007). In conclusion, Koreans were exposed to HAdV-55 in their communities, but the exposure risk was higher among people in military service.

References

Dec 26, 2008·Journal of Clinical Microbiology·Zhen ZhuWenbo Xu
Jan 29, 2014·Influenza and Other Respiratory Viruses·Qing-Bin LuWu-Chun Cao
Apr 23, 2014·Emerging Infectious Diseases·Jung Yeon HeoKang-Won Choe
Mar 14, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Matanelle SalamaMichal Mandelboim
Oct 22, 2016·Emerging Infectious Diseases·Jérémy LafolieCécile Henquell

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