Seroprevalence of SARS-CoV-2 (COVID-19) exposure in pet cats and dogs in Minnesota, USA.

Mythili DileepanYuying Liang


The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 is continuing to spread globally. SARS-CoV-2 infections of feline and canine species have also been reported. However, it is not entirely clear to what extent natural SARS-CoV-2 infection of pet dogs and cats is in households. We have developed enzyme-linked immunosorbent assays (ELISAs) using recombinant SARS-CoV-2 nucleocapsid (N) protein and the receptor-binding-domain (RBD) of the spike protein, and the SARS-CoV-2 spike-pseudotyped vesicular stomatitis virus (VSV)-based neutralization assay to screen serum samples of 239 pet cats and 510 pet dogs in Minnesota in the early phase of the COVID-19 pandemic from mid-April to early June 2020 for evidence of SARS-CoV-2 exposures. A cutoff value was used to identify the seropositive samples in each experiment. The average seroprevalence of N- and RBD-specific antibodies in pet cats were 8% and 3%, respectively. Among nineteen (19) N-seropositive cat sera, fifteen (15) exhibited neutralizing activity and seven (7) were also RBD-seropositive. The N-based ELISA is also specific and does not cross react with antigens of common feline coronaviruses. In contrast, SARS-CoV-2 antibodies were detected at a very low percentage in pet...Continue Reading


Jan 2, 1993·The Veterinary Record·B J TennantC J Gaskell
Mar 23, 2006·Veterinary Microbiology·Simon L PriestnallKerstin Erles
Apr 4, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Simon Lawrence PriestnallKerstin Erles
Feb 9, 2016·Current Opinion in Virology·Rahul Vijay, Stanley Perlman
Aug 16, 2019·Viruses·Shan ZhaoHerman Egberink
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Apr 1, 2020·Nature·Jian ShangFang Li
Apr 1, 2020·International Journal of Biological Sciences·Zi-Wei YeDong-Yan Jin
Apr 8, 2020·Cell Host & Microbe·Young-Il KimYoung Ki Choi
May 12, 2020·Frontiers in Immunology·Cheryl Yi-Pin LeeLisa F P Ng
May 14, 2020·The New England Journal of Medicine·Peter J HalfmannYoshihiro Kawaoka
May 15, 2020·Nature·Thomas H C SitMalik Peiris
Jun 12, 2020·MMWR. Morbidity and Mortality Weekly Report·Alexandra NewmanCasey Barton Behravesh
Jun 20, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Nadia OreshkovaArjan Stegeman
Jun 23, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiumei HuLei Zheng
Jul 15, 2020·Veterinary Pathology·Robert Jan MolenaarWim H M van der Poel
Jul 22, 2020·The Journal of Experimental Medicine·Fabian SchmidtPaul D Bieniasz
Aug 9, 2020·The Journal of Clinical Investigation·Sabra L KleinAaron Ar Tobian
Aug 10, 2020·Veterinary Microbiology·Alison E StoutGary R Whittaker
Aug 25, 2020·The Lancet. Microbe·Kore SchlottauMartin Beer
Aug 28, 2020·Frontiers in Immunology·Vibhuti Kumar ShahSamit Chattopadhyay
Sep 2, 2020·Emerging Microbes & Infections·Qiang ZhangMeilin Jin
Sep 18, 2020·Emerging Infectious Diseases·Vanessa R BarrsThomas H C Sit
Sep 19, 2020·Nature Communications·Dianna L NgCharles Y Chiu
Sep 25, 2020·Emerging Microbes & Infections·Khalid MunirXin Zhao
Oct 9, 2020·Emerging Microbes & Infections·Natasha N GaudreaultJuergen A Richt
Oct 17, 2020·Lancet·Gregory A PolandRichard B Kennedy
Oct 27, 2020·Frontiers in Immunology·Morgan BrisseHinh Ly
Oct 30, 2020·Nature Reviews. Microbiology·Philip V'kovskiVolker Thiel

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.