Seroprevalence of SARS-CoV2 in IBD Patients Treated with Biologic Therapy.

Journal of Crohn's & Colitis
Roberto Berte'Flavio Caprioli

Abstract

A similar course of COVID-19 in patients with inflammatory bowel diseases [IBD] and in the general population has been reported. However, disease prevalence in IBD patients is presently unknown. In this prospective observational study, we aimed at determining SARS-CoV2 infection prevalence in IBD patients treated with biologic therapy. From IBD patients under biologic therapy and recruited from three different locations in Italy and Germany, 354 sera were evaluated for antibody presence by RBD ELISA. Control groups were: i] age-matched healthy subjects tested in the same time period in Milan, Italy; ii] healthy subjects collected in the pre-COVID era; iii] IBD patients under biologic therapy collected in the pre-COVID era. Eight out of 354 patients tested positive for the anti-RBD-SARS-CoV2 IgG antibody [prevalence 2.3%]. The percentage of IgG-positive patients among those recruited from Milan was significantly higher than among those recruited from other locations [prevalence 5.4% vs 0.4%, p <0.005]. IgG-positive patients reported a significantly higher incidence of fever, anosmia, and ageusia, and were more likely to have entered into close contact with COVID-19-positive subjects before the study enrolment. Seroprevalence of ...Continue Reading

References

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May 2, 2020·Gut·Cristina BezzioUNKNOWN Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)
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Oct 7, 2020·Journal of Clinical Medicine·Margherita BruniFederica Facciotti

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Citations

Jan 12, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Fabrizio BossaAngelo Andriulli
Mar 16, 2021·Journal of Crohn's & Colitis·Judith WellensSerre-Yu Wong
Jul 1, 2021·Nature Reviews. Gastroenterology & Hepatology·Markus F Neurath
Aug 28, 2021·Journal of Clinical Medicine·Michał ŁodygaGrażyna Rydzewska

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