Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam

The American Journal of Tropical Medicine and Hygiene
Nguyen Vu TrungBehzad Nadjm

Abstract

AbstractRickettsial infections are recognized as important causes of fever throughout southeast Asia. Herein, we determined the seroprevalence to rickettsioses within rural and urban populations of northern Vietnam. Prevalence of individuals with evidence of prior rickettsial infections (IgG positive) was surprisingly low, with 9.14% (83/908) testing positive to the three major rickettsial serogroups thought to circulate in the region. Prevalence of typhus group rickettsiae (TG)-specific antibodies (6.5%, 58/908) was significantly greater than scrub typhus group orientiae (STG)- or spotted fever group rickettsiae (SFG)-specific antibodies (P < 0.05). The majority of TG seropositives were observed among urban rather than rural residents (P < 0.05). In contrast, overall antibody prevalence to STG and SFG were both very low (1.1%, 10/908 for STG; 1.7%, 15/908 for SFG), with no significant differences between rural and urban residents. These results provide data on baseline population characteristics that may help inform development of Rickettsia serological testing criteria in future clinical studies.

Associated Clinical Trials

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Citations

Nov 4, 2017·PLoS Neglected Tropical Diseases·Guang XuChristine M Arcari
Mar 19, 2019·Emerging Infectious Diseases·Nguyen Vu TrungNguyen Van Kinh
Aug 4, 2020·Vector Borne and Zoonotic Diseases·Sirirat PhomjareetAllen L Richards
Oct 8, 2019·Epidemiology and Infection·Matthew T RobinsonStuart D Blacksell
Apr 18, 2019·EcoHealth·Jaruwan SatjanadumrongStuart D Blacksell
Mar 15, 2019·Emerging Microbes & Infections·Nhiem Le-VietPhilippe Parola
Apr 5, 2020·Tropical Medicine and Infectious Disease·Allen L Richards, Ju Jiang
Aug 25, 2020·3 Biotech·Deepak KalaAnkur Kaushal
Dec 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Philip N D EldersElizabeth A Ashley
Mar 7, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jihye UmJun-Sun Park
May 22, 2021·Asia-Pacific Journal of Public Health·Siraj A KhanR Sabarinanthan

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Methods Mentioned

BETA
serum collections
enzyme-linked immunosorbent assays
ELISA

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