Seroprevalence of severe fever with thrombocytopenia syndrome (SFTS) virus antibodies in humans and animals in Ehime prefecture, Japan, an endemic region of SFTS

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Toshiya KimuraHiroto Shinomiya

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) was first identified as an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV) in China and has also been found to be endemic to Japan and South Korea, indicating that SFTS is of great concern in East Asia. The aim of the present study was to determine the seroprevalence of SFTSV antibodies in humans and animals in SFTS-endemic regions of Japan. One of 694 (0.14%) healthy persons over 50 years of age and 20 of 107 (18.7%) wild and domestic animals in Ehime prefecture of western Japan were determined to be seropositive for SFTSV antibodies by virus neutralization test and ELISA, respectively. The seropositive person, a healthy 74-year-old woman, was a resident of the southwest part of Ehime prefecture engaged in citriculture and field work. This woman's sample exhibited neutralizing activity against SFTSV although she had neither a clear experience with tick bites nor SFTS-like clinical illness. These findings indicate that most people living in the endemic regions are not infected with SFTSV and suggest that most of the SFTS patients reported so far do not reflect the tip of an iceberg of people infected with SFTSV, but at the same time, that SFTSV infection...Continue Reading

Citations

Jun 20, 2019·Human Vaccines & Immunotherapeutics·Joel N MaslowMoonsup Jeong
Mar 21, 2019·The Journal of Veterinary Medical Science·Tsutomu TakedaNaoto Yamabata
Jan 11, 2020·Emerging Microbes & Infections·Tsai-Lu LinChi-Chung Chou
May 7, 2021·Experimental & Molecular Medicine·Mark Anthony CaselYoung Ki Choi
Jul 3, 2021·Viruses·Jun-Won SeoDong-Min Kim
Jul 1, 2021·Annals of Medicine and Surgery·Herwati DualisAzizan Omar
Aug 19, 2021·PLoS Neglected Tropical Diseases·Ji Yun NohWoo Joo Kim
Aug 20, 2021·Ticks and Tick-borne Diseases·Ji-Min RimJoon-Seok Chae

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